Detailed Information on Publication Record
2017
Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis
THOREN, Magnus, E. AZEVEDO, J. DAWSON, J.A. EGIDO, A. FALCOU et. al.Basic information
Original name
Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis
Authors
THOREN, Magnus (752 Sweden), E. AZEVEDO (752 Sweden), J. DAWSON (826 United Kingdom of Great Britain and Northern Ireland), J.A. EGIDO (724 Spain), A. FALCOU (380 Italy), G.A. FORD (826 United Kingdom of Great Britain and Northern Ireland), S. HOLMIN (752 Sweden), Robert MIKULÍK (203 Czech Republic, guarantor, belonging to the institution), J. OLLIKAINEN (246 Finland), N. WAHLGREN (752 Sweden) and N. AHMED (752 Sweden)
Edition
Stroke, Dallas, Lippincott Williams & Wilkins, 2017, 0039-2499
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30210 Clinical neurology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 6.239
RIV identification code
RIV/00216224:14110/17:00100125
Organization unit
Faculty of Medicine
UT WoS
000408438000045
Keywords in English
cerebral edema; cerebral infarct; intracerebral hemorrhage; outcome; thrombolysis
Změněno: 8/2/2021 15:29, Mgr. Tereza Miškechová
Abstract
V originále
Background and Purpose-Cerebral edema (CED) is a severe complication of acute ischemic stroke. There is uncertainty regarding the predictors for the development of CED after cerebral infarction. We aimed to determine which baseline clinical and radiological parameters predict development of CED in patients treated with intravenous thrombolysis. Methods-We used an image-based classification of CED with 3 degrees of severity (less severe CED 1 and most severe CED 3) on postintravenous thrombolysis imaging scans. We extracted data from 42 187 patients recorded in the SITS International Register (Safe Implementation of Treatments in Stroke) during 2002 to 2011. We did univariate comparisons of baseline data between patients with or without CED. We used backward logistic regression to select a set of predictors for each CED severity. Results-CED was detected in 9579/42 187 patients (22.7%: 12.5% CED 1, 4.9% CED 2, 5.3% CED 3). In patients with CED versus no CED, the baseline National Institutes of Health Stroke Scale score was higher (17 versus 10; P<0.001), signs of acute infarct was more common (27.9% versus 19.2%; P<0.001), hyperdense artery sign was more common (37.6% versus 14.6%; P<0.001), and blood glucose was higher (6.8 versus 6.4 mmol/L; P<0.001). Baseline National Institutes of Health Stroke Scale, hyperdense artery sign, blood glucose, impaired consciousness, and signs of acute infarct on imaging were independent predictors for all edema types. Conclusions-The most important baseline predictors for early CED are National Institutes of Health Stroke Scale, hyperdense artery sign, higher blood glucose, decreased level of consciousness, and signs of infarct at baseline. The findings can be used to improve selection and monitoring of patients for drug or surgical treatment.
Links
| LM2015090, research and development project |
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