Systemic Inflammation in Midlife: Race, Socioeconomic Status,
and Perceived Discrimination

J 2017

Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

ŠTĚPANÍKOVÁ, Irena, Lori Brand BATEMAN and Gabriela R. OATES

Basic information

Original name

Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination

Authors

ŠTĚPANÍKOVÁ, Irena (203 Czech Republic, guarantor, belonging to the institution), Lori Brand BATEMAN (840 United States of America) and Gabriela R. OATES (840 United States of America)

Edition

AMERICAN JOURNAL OF PREVENTIVE MEDICINE, NEW YORK, ELSEVIER SCIENCE INC, 2017, 0749-3797

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.127

RIV identification code

RIV/00216224:14310/17:00100126

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.amepre.2016.09.026

UT WoS

000390667100009

Keywords in English

C-REACTIVE PROTEIN; 2005-2010 NHANES DATA; AFRICAN-AMERICAN; CARDIOVASCULAR RISK; UNITED-STATES; SOCIAL DETERMINANTS; DEPRESSIVE SYMPTOMS; POLICY IMPLICATIONS; RACIAL DISPARITIES; INSULIN-RESISTANCE

Abstract

V originále

Introduction: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. Methods: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin. For each biomarker, series of multivariate linear regression models were estimated for the pooled sample and separately for blacks and whites. Full models included social determinants; psychological, lifestyle, and health factors; and demographic covariates. Results: Bivariate analyses indicated higher concentrations of all inflammation markers among blacks compared with whites (p < 0.001). In fully adjusted models using the pooled sample, racial differences persisted for interleukin 6 (p < 0.001) and fibrinogen (p < 0.01). For E-selectin and C-reactive protein, racial differences were explained after adjusting for covariates. Education was linked to lower fibrinogen concentration (p < 0.05) in the fully adjusted model and C-reactive protein concentration (p < 0.01) after adjusting for demographic factors and income. Lifetime perceived discrimination was related to higher concentrations of fibrinogen (p < 0.05) in the fully adjusted model, and higher concentrations of E-selectin and interleukin 6 (p < 0.05) after adjusting for socioeconomic status (SES) and demographic factors. Conclusions: This study clarifies the contributions of race, SES, and perceived discrimination to inflammation. It suggests that inflammation-reducing interventions should focus on blacks and individuals facing socioeconomic disadvantages, especially low education.

Citovat

ŠTĚPANÍKOVÁ, Irena, Lori Brand BATEMAN and Gabriela R. OATES. Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination. AMERICAN JOURNAL OF PREVENTIVE MEDICINE. NEW YORK: ELSEVIER SCIENCE INC, 2017, vol. 52, No 1, p. "S63"-"S76", 14 pp. ISSN 0749-3797. Available from: https://dx.doi.org/10.1016/j.amepre.2016.09.026.

@article{1409476,
   author = {Štěpaníková, Irena and Bateman, Lori Brand and Oates, Gabriela R.},
   article_location = {NEW YORK},
   article_number = {1},
   doi = {http://dx.doi.org/10.1016/j.amepre.2016.09.026},
   keywords = {C-REACTIVE PROTEIN; 2005-2010 NHANES DATA; AFRICAN-AMERICAN; CARDIOVASCULAR RISK; UNITED-STATES; SOCIAL DETERMINANTS; DEPRESSIVE SYMPTOMS; POLICY IMPLICATIONS; RACIAL DISPARITIES; INSULIN-RESISTANCE},
   language = {eng},
   issn = {0749-3797},
   journal = {AMERICAN JOURNAL OF PREVENTIVE MEDICINE},
   title = {Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination},
   url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf},
   volume = {52},
   year = {2017}
}

TY  - JOUR
ID  - 1409476
AU  - Štěpaníková, Irena - Bateman, Lori Brand - Oates, Gabriela R.
PY  - 2017
TI  - Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination
JF  - AMERICAN JOURNAL OF PREVENTIVE MEDICINE
VL  - 52
IS  - 1
SP  - "S63"-"S76"
EP  - "S63"-"S76"
PB  - ELSEVIER SCIENCE INC
SN  - 07493797
KW  - C-REACTIVE PROTEIN
KW  - 2005-2010 NHANES DATA
KW  - AFRICAN-AMERICAN
KW  - CARDIOVASCULAR RISK
KW  - UNITED-STATES
KW  - SOCIAL DETERMINANTS
KW  - DEPRESSIVE SYMPTOMS
KW  - POLICY IMPLICATIONS
KW  - RACIAL DISPARITIES
KW  - INSULIN-RESISTANCE
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf
L2  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf
N2  - Introduction: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. Methods: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin. For each biomarker, series of multivariate linear regression models were estimated for the pooled sample and separately for blacks and whites. Full models included social determinants; psychological, lifestyle, and health factors; and demographic covariates. Results: Bivariate analyses indicated higher concentrations of all inflammation markers among blacks compared with whites (p < 0.001). In fully adjusted models using the pooled sample, racial differences persisted for interleukin 6 (p < 0.001) and fibrinogen (p < 0.01). For E-selectin and C-reactive protein, racial differences were explained after adjusting for covariates. Education was linked to lower fibrinogen concentration (p < 0.05) in the fully adjusted model and C-reactive protein concentration (p < 0.01) after adjusting for demographic factors and income. Lifetime perceived discrimination was related to higher concentrations of fibrinogen (p < 0.05) in the fully adjusted model, and higher concentrations of E-selectin and interleukin 6 (p < 0.05) after adjusting for socioeconomic status (SES) and demographic factors. Conclusions: This study clarifies the contributions of race, SES, and perceived discrimination to inflammation. It suggests that inflammation-reducing interventions should focus on blacks and individuals facing socioeconomic disadvantages, especially low education.
ER  -

ŠTĚPANÍKOVÁ, Irena, Lori Brand BATEMAN and Gabriela R. OATES. Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination. \textit{AMERICAN JOURNAL OF PREVENTIVE MEDICINE}. NEW YORK: ELSEVIER SCIENCE INC, 2017, vol.~52, No~1, p.~''S63''-''S76'', 14 pp. ISSN~0749-3797. Available from: https://dx.doi.org/10.1016/j.amepre.2016.09.026.

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