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@article{1409476,
author = {Štěpaníková, Irena and Bateman, Lori Brand and Oates, Gabriela R.},
article_location = {NEW YORK},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.amepre.2016.09.026},
keywords = {C-REACTIVE PROTEIN; 2005-2010 NHANES DATA; AFRICAN-AMERICAN; CARDIOVASCULAR RISK; UNITED-STATES; SOCIAL DETERMINANTS; DEPRESSIVE SYMPTOMS; POLICY IMPLICATIONS; RACIAL DISPARITIES; INSULIN-RESISTANCE},
language = {eng},
issn = {0749-3797},
journal = {AMERICAN JOURNAL OF PREVENTIVE MEDICINE},
title = {Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination},
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf},
volume = {52},
year = {2017}
}
TY - JOUR
ID - 1409476
AU - Štěpaníková, Irena - Bateman, Lori Brand - Oates, Gabriela R.
PY - 2017
TI - Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination
JF - AMERICAN JOURNAL OF PREVENTIVE MEDICINE
VL - 52
IS - 1
SP - "S63"-"S76"
EP - "S63"-"S76"
PB - ELSEVIER SCIENCE INC
SN - 07493797
KW - C-REACTIVE PROTEIN
KW - 2005-2010 NHANES DATA
KW - AFRICAN-AMERICAN
KW - CARDIOVASCULAR RISK
KW - UNITED-STATES
KW - SOCIAL DETERMINANTS
KW - DEPRESSIVE SYMPTOMS
KW - POLICY IMPLICATIONS
KW - RACIAL DISPARITIES
KW - INSULIN-RESISTANCE
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf
L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319849/pdf/nihms847486.pdf
N2 - Introduction: This study investigates social determinants of systemic inflammation, focusing on race, SES, and perceived discrimination. Methods: Data on 884 white and 170 black participants were obtained from the Survey of Midlife in the U.S., a cross-sectional observational study combining survey measures, anthropometry, and biomarker assay. Data, collected in 2004-2009, were analyzed in 2016. Main outcome measures were fasting blood concentrations of C-reactive protein, interleukin 6, fibrinogen, and E-selectin. For each biomarker, series of multivariate linear regression models were estimated for the pooled sample and separately for blacks and whites. Full models included social determinants; psychological, lifestyle, and health factors; and demographic covariates. Results: Bivariate analyses indicated higher concentrations of all inflammation markers among blacks compared with whites (p < 0.001). In fully adjusted models using the pooled sample, racial differences persisted for interleukin 6 (p < 0.001) and fibrinogen (p < 0.01). For E-selectin and C-reactive protein, racial differences were explained after adjusting for covariates. Education was linked to lower fibrinogen concentration (p < 0.05) in the fully adjusted model and C-reactive protein concentration (p < 0.01) after adjusting for demographic factors and income. Lifetime perceived discrimination was related to higher concentrations of fibrinogen (p < 0.05) in the fully adjusted model, and higher concentrations of E-selectin and interleukin 6 (p < 0.05) after adjusting for socioeconomic status (SES) and demographic factors. Conclusions: This study clarifies the contributions of race, SES, and perceived discrimination to inflammation. It suggests that inflammation-reducing interventions should focus on blacks and individuals facing socioeconomic disadvantages, especially low education.
ER -
ŠTĚPANÍKOVÁ, Irena, Lori Brand BATEMAN and Gabriela R. OATES. Systemic Inflammation in Midlife: Race, Socioeconomic Status, and Perceived Discrimination. \textit{AMERICAN JOURNAL OF PREVENTIVE MEDICINE}. NEW YORK: ELSEVIER SCIENCE INC, 2017, vol.~52, No~1, p.~''S63''-''S76'', 14 pp. ISSN~0749-3797. Available from: https://dx.doi.org/10.1016/j.amepre.2016.09.026.
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