KULKARNI, M., I. JUNKAR, Petr HUMPOLÍČEK, Z. CAPAKOVA, Katarzyna Anna RADASZKIEWICZ, N. MIKUSOVA, Jiří PACHERNÍK, Marián LEHOCKÝ, A. IGLIC, Markéta HANÁČKOVÁ and M. MOZETIC. Interaction of nanostructured TiO2 biointerfaces with stern cells and biofilm-forming bacteria. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. AMSTERDAM: ELSEVIER SCIENCE BV, vol. 77, August, p. 500-507. ISSN 0928-4931. doi:10.1016/j.msec.2017.03.174. 2017.
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Basic information
Original name Interaction of nanostructured TiO2 biointerfaces with stern cells and biofilm-forming bacteria
Authors KULKARNI, M. (705 Slovenia), I. JUNKAR (705 Slovenia), Petr HUMPOLÍČEK (203 Czech Republic, guarantor, belonging to the institution), Z. CAPAKOVA (203 Czech Republic), Katarzyna Anna RADASZKIEWICZ (616 Poland, belonging to the institution), N. MIKUSOVA (203 Czech Republic), Jiří PACHERNÍK (203 Czech Republic, belonging to the institution), Marián LEHOCKÝ (203 Czech Republic, belonging to the institution), A. IGLIC (705 Slovenia), Markéta HANÁČKOVÁ (203 Czech Republic, belonging to the institution) and M. MOZETIC (705 Slovenia).
Edition MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, AMSTERDAM, ELSEVIER SCIENCE BV, 2017, 0928-4931.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10601 Cell biology
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.080
RIV identification code RIV/00216224:14310/17:00100154
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.msec.2017.03.174
UT WoS 000403381200057
Keywords in English Nanotubes; Titanium; Biofilm; Stem cells; Surface morphology
Tags NZ, rivok
Tags International impact, Reviewed
Changed by Changed by: Ing. Nicole Zrilić, učo 240776. Changed: 5/4/2018 15:14.
Abstract
Nanostructured TiO2 nanotubes (NTs) of diameters from 15 to 100 nm were fabricated by an electrochemical anodization process. Biofilm-positive strains of Bacillus cereus and Pseudomonas aeruginosa behaved similarly on all TiO2 NTs as well as on native titanium (Ti) foil. The adhesion and growth of mesenchymal stem cells (MSc), embryonic stem cells (ESc), and pure cardiomyocytes derived from ESc exhibited significant differences. MSc as well as ESc were, in contrast to cardiomyocytes, able to adhere, and grow on TiO2 NTs. A correlation between NTs diameter and cell behaviour was however observed in the case of MSc and ESc. MSc were not in a physiological state in the case of 100 nm TiO2 NTs, while ESc were not able to grow on 15 nm TiO2 NTs. It can be stated that these differences can be assigned to different diameters of the NTs but not to the chemistry of the surface. This is the first study describing the comprehensive behaviour of both eukaryotic and prokaryotic cells on TiO2 NTs. On the basis of obtained results, it can be concluded that new generation of medical devices providing selective cell behaviour can be fabricated by optimizing the nanoscale morphology of TiO2. (C) 2017 Elsevier B.V. All rights reserved.
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