Legacy and alternative halogenated flame retardants in human
milk in Europe: Implications for children's health

J 2017

Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health

ČECHOVÁ, Eliška, Šimon VOJTA, Petr KUKUČKA, Anton KOČAN, Tomáš TRNOVEC et. al.

Basic information

Original name

Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health

Authors

ČECHOVÁ, Eliška (203 Czech Republic, belonging to the institution), Šimon VOJTA (203 Czech Republic, belonging to the institution), Petr KUKUČKA (203 Czech Republic, belonging to the institution), Anton KOČAN (703 Slovakia, belonging to the institution), Tomáš TRNOVEC (703 Slovakia), Lubica MURINOVA PALKOVICOVA (703 Slovakia), Marijke DE COCK (528 Netherlands), Margot VAN DE BOR (528 Netherlands), Joakim ASKEVOLD (578 Norway), Merete EGGESBO (578 Norway) and Martin SCHERINGER (756 Switzerland, guarantor, belonging to the institution)

Edition

Environment International, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2017, 0160-4120

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.297

RIV identification code

RIV/00216224:14310/17:00100156

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.envint.2017.08.008

UT WoS

000411604400014

Keywords in English

Alternative flame retardants; Developmental neurotoxicants; Human milk; Infant exposure; Polybrominated diphenyl ethers

Abstract

V originále

In this study, 10 polybrominated diphenyl ethers (PBDEs) and 19 alternative halogenated flame retardants (AFRs) were determined in >450 human milk samples across three European countries, representing northern, western and eastern Europe. This study provides first insights into the occurrence of selected AFRs in mother milk samples and compares them among three European countries. Sums of median concentrations of the most frequently detected PBDEs were 2.16, 0.88 and 0.45 ng g(-1) lipid weight (lw) in Norway, the Netherlands and Slovakia, respectively. The sum of the concentrations of AFRs ranged from 0.14 to 0.25 ng g(-1) lw in all countries, which was 2 to 15 times less compared to S7PBDEs. The Penta-BDE replacement, bis(2-ethylhexyl) tetrabromophthalate, BEH-TEBP, was present at the greatest concentrations of any of the AFRs and in some samples exceeded concentrations of BDE 47 and BDE 153. Four AFRs including bromobenzenes (hexabromobenzene, pentabromobenzene, pentabromotoluene) and another Penta-BDE replacement (2-ethylhexyl-2,3,4,5-tetrabromobenzoate, EH-TBB) were detected in >42% of all human milk samples. Because of the potential developmental neurotoxicity of the halogenated flame retardants, infant dietary intakes via breastfeeding were estimated; in four cases the intakes of BDE 47 exceeded the reference dose indicating that the present concentrations may pose a risk for children.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

LO1214, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX)

Investor: Ministry of Education, Youth and Sports of the CR

282957, interní kód MU

Name: DENAMIC - Developmental neurotoxicity assessment of mixtures in children (Acronym: DENAMIC)

Investor: European Union, Cooperation

Citovat

ČECHOVÁ, Eliška, Šimon VOJTA, Petr KUKUČKA, Anton KOČAN, Tomáš TRNOVEC, Lubica MURINOVA PALKOVICOVA, Marijke DE COCK, Margot VAN DE BOR, Joakim ASKEVOLD, Merete EGGESBO and Martin SCHERINGER. Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health. Environment International. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, vol. 108, November, p. 137-145. ISSN 0160-4120. Available from: https://dx.doi.org/10.1016/j.envint.2017.08.008.

@article{1409698,
   author = {Čechová, Eliška and Vojta, Šimon and Kukučka, Petr and Kočan, Anton and Trnovec, Tomáš and Murinova Palkovicova, Lubica and de Cock, Marijke and van de Bor, Margot and Askevold, Joakim and Eggesbo, Merete and Scheringer, Martin},
   article_location = {OXFORD},
   article_number = {November},
   doi = {http://dx.doi.org/10.1016/j.envint.2017.08.008},
   keywords = {Alternative flame retardants; Developmental neurotoxicants; Human milk; Infant exposure; Polybrominated diphenyl ethers},
   language = {eng},
   issn = {0160-4120},
   journal = {Environment International},
   title = {Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health},
   url = {https://www.sciencedirect.com/science/article/pii/S0160412017306918?via%3Dihub},
   volume = {108},
   year = {2017}
}

TY  - JOUR
ID  - 1409698
AU  - Čechová, Eliška - Vojta, Šimon - Kukučka, Petr - Kočan, Anton - Trnovec, Tomáš - Murinova Palkovicova, Lubica - de Cock, Marijke - van de Bor, Margot - Askevold, Joakim - Eggesbo, Merete - Scheringer, Martin
PY  - 2017
TI  - Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health
JF  - Environment International
VL  - 108
IS  - November
SP  - 137-145
EP  - 137-145
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 01604120
KW  - Alternative flame retardants
KW  - Developmental neurotoxicants
KW  - Human milk
KW  - Infant exposure
KW  - Polybrominated diphenyl ethers
UR  - https://www.sciencedirect.com/science/article/pii/S0160412017306918?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0160412017306918?via%3Dihub
N2  - In this study, 10 polybrominated diphenyl ethers (PBDEs) and 19 alternative halogenated flame retardants (AFRs) were determined in >450 human milk samples across three European countries, representing northern, western and eastern Europe. This study provides first insights into the occurrence of selected AFRs in mother milk samples and compares them among three European countries. Sums of median concentrations of the most frequently detected PBDEs were 2.16, 0.88 and 0.45 ng g(-1) lipid weight (lw) in Norway, the Netherlands and Slovakia, respectively. The sum of the concentrations of AFRs ranged from 0.14 to 0.25 ng g(-1) lw in all countries, which was 2 to 15 times less compared to S7PBDEs. The Penta-BDE replacement, bis(2-ethylhexyl) tetrabromophthalate, BEH-TEBP, was present at the greatest concentrations of any of the AFRs and in some samples exceeded concentrations of BDE 47 and BDE 153. Four AFRs including bromobenzenes (hexabromobenzene, pentabromobenzene, pentabromotoluene) and another Penta-BDE replacement (2-ethylhexyl-2,3,4,5-tetrabromobenzoate, EH-TBB) were detected in >42% of all human milk samples. Because of the potential developmental neurotoxicity of the halogenated flame retardants, infant dietary intakes via breastfeeding were estimated; in four cases the intakes of BDE 47 exceeded the reference dose indicating that the present concentrations may pose a risk for children.
ER  -

ČECHOVÁ, Eliška, Šimon VOJTA, Petr KUKUČKA, Anton KOČAN, Tomáš TRNOVEC, Lubica MURINOVA PALKOVICOVA, Marijke DE COCK, Margot VAN DE BOR, Joakim ASKEVOLD, Merete EGGESBO and Martin SCHERINGER. Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health. \textit{Environment International}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, vol.~108, November, p.~137-145. ISSN~0160-4120. Available from: https://dx.doi.org/10.1016/j.envint.2017.08.008.

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