Development of a bioanalytical test battery for water quality
monitoring: Fingerprinting identified micropollutants and their
Contribution to effects in surface water

J 2017

Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water

NEALE, Peta A., Rolf ALTENBURGER, Selim AIT-AISSA, Francois BRION, Wibke BUSCH et. al.

Basic information

Original name

Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water

Authors

NEALE, Peta A. (36 Australia), Rolf ALTENBURGER (276 Germany), Selim AIT-AISSA (250 France), Francois BRION (250 France), Wibke BUSCH (276 Germany), Gisela de Aragao UMBUZEIRO (76 Brazil), Michael S. DENISON (840 United States of America), David DU PASQUIER (250 France), Klára HILSCHEROVÁ (203 Czech Republic, guarantor, belonging to the institution), Henner HOLLERT (276 Germany), Daniel A. MORALES (76 Brazil), Jiří NOVÁK (203 Czech Republic, belonging to the institution), Rita SCHLICHTING (276 Germany), Thomas-Benjamin SEILER (276 Germany), Helene SERRA (250 France), Ying SHAO (276 Germany), Andrew J. TINDALL (250 France), Knut Erik TOLLEFSEN (578 Norway), Timothy D. WILLIAMS (826 United Kingdom of Great Britain and Northern Ireland) and Beate I. ESCHER (276 Germany)

Edition

Water Research, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2017, 0043-1354

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10503 Water resources

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.051

RIV identification code

RIV/00216224:14310/17:00100299

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.watres.2017.07.016

UT WoS

000410010500071

Keywords in English

In vitro; Cell-based bioassay; In vivo; Fish embryo toxicity test; ToxCast; Mixture toxicity

Abstract

V originále

Surface waters can contain a diverse range of organic pollutants, including pesticides, pharmaceuticals and industrial compounds. While bioassays have been used for water quality monitoring, there is limited knowledge regarding the effects of individual micropollutants and their relationship to the overall mixture effect in water samples. In this study, a battery of in vitro bioassays based on human and fish cell lines and whole organism assays using bacteria, algae, daphnids and fish embryos was assembled for use in water quality monitoring. The selection of bioassays was guided by the principles of adverse outcome pathways in order to cover relevant steps in toxicity pathways known to be triggered by environmental water samples. The effects of 34 water pollutants, which were selected based on hazard quotients, available environmental quality standards and mode of action information, were fingerprinted in the bioassay test battery. There was a relatively good agreement between the experimental results and available literature effect data. The majority of the chemicals were active in the assays indicative of apical effects, while fewer chemicals had a response in the specific reporter gene assays, but these effects were typically triggered at lower concentrations. The single chemical effect data were used to improve published mixture toxicity modeling of water samples from the Danube River. While there was a slight increase in the fraction of the bioanalytical equivalents explained for the Danube River samples, for some endpoints less than 1% of the observed effect could be explained by the studied chemicals. The new mixture models essentially confirmed previous findings from many studies monitoring water quality using both chemical analysis and bioanalytical tools. In short, our results indicate that many more chemicals contribute to the biological effect than those that are typically quantified by chemical monitoring programs or those regulated by environmental quality standards. This study not only demonstrates the utility of fingerprinting single chemicals for an improved understanding of the biological effect of pollutants, but also highlights the need to apply bioassays for water quality monitoring in order to prevent underestimation of the overall biological effect..

Links

603437, interní kód MU

Name: SOLUTIONS - Solutions for present and future emerging pollutants in land and water resources management (Acronym: SOLUTIONS)

Investor: European Union, Cooperation

Citovat

NEALE, Peta A., Rolf ALTENBURGER, Selim AIT-AISSA, Francois BRION, Wibke BUSCH, Gisela de Aragao UMBUZEIRO, Michael S. DENISON, David DU PASQUIER, Klára HILSCHEROVÁ, Henner HOLLERT, Daniel A. MORALES, Jiří NOVÁK, Rita SCHLICHTING, Thomas-Benjamin SEILER, Helene SERRA, Ying SHAO, Andrew J. TINDALL, Knut Erik TOLLEFSEN, Timothy D. WILLIAMS and Beate I. ESCHER. Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water. Water Research. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, vol. 123, October, p. 734-750. ISSN 0043-1354. Available from: https://dx.doi.org/10.1016/j.watres.2017.07.016.

@article{1410521,
   author = {Neale, Peta A. and Altenburger, Rolf and AitandAissa, Selim and Brion, Francois and Busch, Wibke and Umbuzeiro, Gisela de Aragao and Denison, Michael S. and Du Pasquier, David and Hilscherová, Klára and Hollert, Henner and Morales, Daniel A. and Novák, Jiří and Schlichting, Rita and Seiler, ThomasandBenjamin and Serra, Helene and Shao, Ying and Tindall, Andrew J. and Tollefsen, Knut Erik and Williams, Timothy D. and Escher, Beate I.},
   article_location = {OXFORD},
   article_number = {October},
   doi = {http://dx.doi.org/10.1016/j.watres.2017.07.016},
   keywords = {In vitro; Cell-based bioassay; In vivo; Fish embryo toxicity test; ToxCast; Mixture toxicity},
   language = {eng},
   issn = {0043-1354},
   journal = {Water Research},
   title = {Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water},
   url = {https://www.sciencedirect.com/science/article/pii/S0043135417305894?via%3Dihub},
   volume = {123},
   year = {2017}
}

TY  - JOUR
ID  - 1410521
AU  - Neale, Peta A. - Altenburger, Rolf - Ait-Aissa, Selim - Brion, Francois - Busch, Wibke - Umbuzeiro, Gisela de Aragao - Denison, Michael S. - Du Pasquier, David - Hilscherová, Klára - Hollert, Henner - Morales, Daniel A. - Novák, Jiří - Schlichting, Rita - Seiler, Thomas-Benjamin - Serra, Helene - Shao, Ying - Tindall, Andrew J. - Tollefsen, Knut Erik - Williams, Timothy D. - Escher, Beate I.
PY  - 2017
TI  - Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water
JF  - Water Research
VL  - 123
IS  - October
SP  - 734-750
EP  - 734-750
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 00431354
KW  - In vitro
KW  - Cell-based bioassay
KW  - In vivo
KW  - Fish embryo toxicity test
KW  - ToxCast
KW  - Mixture toxicity
UR  - https://www.sciencedirect.com/science/article/pii/S0043135417305894?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0043135417305894?via%3Dihub
N2  - Surface waters can contain a diverse range of organic pollutants, including pesticides, pharmaceuticals and industrial compounds. While bioassays have been used for water quality monitoring, there is limited knowledge regarding the effects of individual micropollutants and their relationship to the overall mixture effect in water samples. In this study, a battery of in vitro bioassays based on human and fish cell lines and whole organism assays using bacteria, algae, daphnids and fish embryos was assembled for use in water quality monitoring. The selection of bioassays was guided by the principles of adverse outcome pathways in order to cover relevant steps in toxicity pathways known to be triggered by environmental water samples. The effects of 34 water pollutants, which were selected based on hazard quotients, available environmental quality standards and mode of action information, were fingerprinted in the bioassay test battery. There was a relatively good agreement between the experimental results and available literature effect data. The majority of the chemicals were active in the assays indicative of apical effects, while fewer chemicals had a response in the specific reporter gene assays, but these effects were typically triggered at lower concentrations. The single chemical effect data were used to improve published mixture toxicity modeling of water samples from the Danube River. While there was a slight increase in the fraction of the bioanalytical equivalents explained for the Danube River samples, for some endpoints less than 1% of the observed effect could be explained by the studied chemicals. The new mixture models essentially confirmed previous findings from many studies monitoring water quality using both chemical analysis and bioanalytical tools. In short, our results indicate that many more chemicals contribute to the biological effect than those that are typically quantified by chemical monitoring programs or those regulated by environmental quality standards. This study not only demonstrates the utility of fingerprinting single chemicals for an improved understanding of the biological effect of pollutants, but also highlights the need to apply bioassays for water quality monitoring in order to prevent underestimation of the overall biological effect..
ER  -

NEALE, Peta A., Rolf ALTENBURGER, Selim AIT-AISSA, Francois BRION, Wibke BUSCH, Gisela de Aragao UMBUZEIRO, Michael S. DENISON, David DU PASQUIER, Klára HILSCHEROVÁ, Henner HOLLERT, Daniel A. MORALES, Jiří NOVÁK, Rita SCHLICHTING, Thomas-Benjamin SEILER, Helene SERRA, Ying SHAO, Andrew J. TINDALL, Knut Erik TOLLEFSEN, Timothy D. WILLIAMS and Beate I. ESCHER. Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their Contribution to effects in surface water. \textit{Water Research}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2017, vol.~123, October, p.~734-750. ISSN~0043-1354. Available from: https://dx.doi.org/10.1016/j.watres.2017.07.016.

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