QUIN, J.E., I. BUJILA, M. CHERIF, G.S. SANOU, Y. QU, MV HOMANN, A. ROLICKA, S.B. SIRIMA, Mary Anne O'CONNELL, A. LENNARTSSON, M. TROYE-BLOMBERG, I. NEBIE and A.K.O. FARRANT. Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria. elife. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, 2017, vol. 6, SEP, p. nestránkováno, 19 pp. ISSN 2050-084X. Available from: https://dx.doi.org/10.7554/eLife.29156. |
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@article{1410901, author = {Quin, J.E. and Bujila, I. and Cherif, M. and Sanou, G.S. and Qu, Y. and Homann, MV and Rolicka, A. and Sirima, S.B. and O'Connell, Mary Anne and Lennartsson, A. and TroyeandBlomberg, M. and Nebie, I. and Farrant, A.K.O.}, article_location = {CAMBRIDGE}, article_number = {SEP}, doi = {http://dx.doi.org/10.7554/eLife.29156}, keywords = {PLASMODIUM-FALCIPARUM MALARIA; GAMMA-RIIA POLYMORPHISM; ACUTE MYELOID-LEUKEMIA; BURKINA-FASO; WEST-AFRICA; INFLAMMASOME ACTIVATION; EPIGENETIC REGULATION; TRAINED IMMUNITY; INNATE IMMUNITY; BINDING-SITES}, language = {eng}, issn = {2050-084X}, journal = {elife}, title = {Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria}, url = {https://cdn.elifesciences.org/articles/29156/elife-29156-v2.pdf}, volume = {6}, year = {2017} }
TY - JOUR ID - 1410901 AU - Quin, J.E. - Bujila, I. - Cherif, M. - Sanou, G.S. - Qu, Y. - Homann, MV - Rolicka, A. - Sirima, S.B. - O'Connell, Mary Anne - Lennartsson, A. - Troye-Blomberg, M. - Nebie, I. - Farrant, A.K.O. PY - 2017 TI - Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria JF - elife VL - 6 IS - SEP SP - nestránkováno EP - nestránkováno PB - ELIFE SCIENCES PUBLICATIONS LTD SN - 2050084X KW - PLASMODIUM-FALCIPARUM MALARIA KW - GAMMA-RIIA POLYMORPHISM KW - ACUTE MYELOID-LEUKEMIA KW - BURKINA-FASO KW - WEST-AFRICA KW - INFLAMMASOME ACTIVATION KW - EPIGENETIC REGULATION KW - TRAINED IMMUNITY KW - INNATE IMMUNITY KW - BINDING-SITES UR - https://cdn.elifesciences.org/articles/29156/elife-29156-v2.pdf L2 - https://cdn.elifesciences.org/articles/29156/elife-29156-v2.pdf N2 - The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite densities compared to sympatric ethnic groups. However, the basis for this lower susceptibility to malaria by the Fulani is unknown. The incidence of classic malaria resistance genes are lower in the Fulani than in other sympatric ethnic populations, and targeted SNP analyses of other candidate genes involved in the immune response to malaria have not been able to account for the observed difference in the Fulani susceptibility to P.falciparum. Therefore, we have performed a pilot study to examine global transcription and DNA methylation patterns in specific immune cell populations in the Fulani to elucidate the mechanisms that confer the lower susceptibility to P.falciparum malaria. When we compared uninfected and infected Fulani individuals, in contrast to uninfected and infected individuals from the sympatric ethnic group Mossi, we observed a key difference: a strong transcriptional response was only detected in the monocyte fraction of the Fulani, where over 1000 genes were significantly differentially expressed upon P.falciparum infection. ER -
QUIN, J.E., I. BUJILA, M. CHERIF, G.S. SANOU, Y. QU, MV HOMANN, A. ROLICKA, S.B. SIRIMA, Mary Anne O'CONNELL, A. LENNARTSSON, M. TROYE-BLOMBERG, I. NEBIE and A.K.O. FARRANT. Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria. \textit{elife}. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, 2017, vol.~6, SEP, p.~nestránkováno, 19 pp. ISSN~2050-084X. Available from: https://dx.doi.org/10.7554/eLife.29156.
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