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@article{1410901,
author = {Quin, J.E. and Bujila, I. and Cherif, M. and Sanou, G.S. and Qu, Y. and Homann, MV and Rolicka, A. and Sirima, S.B. and O'Connell, Mary Anne and Lennartsson, A. and TroyeandBlomberg, M. and Nebie, I. and Farrant, A.K.O.},
article_location = {CAMBRIDGE},
article_number = {SEP},
doi = {http://dx.doi.org/10.7554/eLife.29156},
keywords = {PLASMODIUM-FALCIPARUM MALARIA; GAMMA-RIIA POLYMORPHISM; ACUTE MYELOID-LEUKEMIA; BURKINA-FASO; WEST-AFRICA; INFLAMMASOME ACTIVATION; EPIGENETIC REGULATION; TRAINED IMMUNITY; INNATE IMMUNITY; BINDING-SITES},
language = {eng},
issn = {2050-084X},
journal = {elife},
title = {Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria},
url = {https://cdn.elifesciences.org/articles/29156/elife-29156-v2.pdf},
volume = {6},
year = {2017}
}
TY - JOUR
ID - 1410901
AU - Quin, J.E. - Bujila, I. - Cherif, M. - Sanou, G.S. - Qu, Y. - Homann, MV - Rolicka, A. - Sirima, S.B. - O'Connell, Mary Anne - Lennartsson, A. - Troye-Blomberg, M. - Nebie, I. - Farrant, A.K.O.
PY - 2017
TI - Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria
JF - elife
VL - 6
IS - SEP
SP - nestránkováno
EP - nestránkováno
PB - ELIFE SCIENCES PUBLICATIONS LTD
SN - 2050084X
KW - PLASMODIUM-FALCIPARUM MALARIA
KW - GAMMA-RIIA POLYMORPHISM
KW - ACUTE MYELOID-LEUKEMIA
KW - BURKINA-FASO
KW - WEST-AFRICA
KW - INFLAMMASOME ACTIVATION
KW - EPIGENETIC REGULATION
KW - TRAINED IMMUNITY
KW - INNATE IMMUNITY
KW - BINDING-SITES
UR - https://cdn.elifesciences.org/articles/29156/elife-29156-v2.pdf
L2 - https://cdn.elifesciences.org/articles/29156/elife-29156-v2.pdf
N2 - The Fulani ethnic group has relatively better protection from Plasmodium falciparum malaria, as reflected by fewer symptomatic cases of malaria, lower infection rates, and lower parasite densities compared to sympatric ethnic groups. However, the basis for this lower susceptibility to malaria by the Fulani is unknown. The incidence of classic malaria resistance genes are lower in the Fulani than in other sympatric ethnic populations, and targeted SNP analyses of other candidate genes involved in the immune response to malaria have not been able to account for the observed difference in the Fulani susceptibility to P.falciparum. Therefore, we have performed a pilot study to examine global transcription and DNA methylation patterns in specific immune cell populations in the Fulani to elucidate the mechanisms that confer the lower susceptibility to P.falciparum malaria. When we compared uninfected and infected Fulani individuals, in contrast to uninfected and infected individuals from the sympatric ethnic group Mossi, we observed a key difference: a strong transcriptional response was only detected in the monocyte fraction of the Fulani, where over 1000 genes were significantly differentially expressed upon P.falciparum infection.
ER -
QUIN, J.E., I. BUJILA, M. CHERIF, G.S. SANOU, Y. QU, MV HOMANN, A. ROLICKA, S.B. SIRIMA, Mary Anne O'CONNELL, A. LENNARTSSON, M. TROYE-BLOMBERG, I. NEBIE and A.K.O. FARRANT. Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria. \textit{elife}. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD, vol.~6, SEP, p.~nestránkováno, 19 pp. ISSN~2050-084X. doi:10.7554/eLife.29156. 2017.
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