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@article{1411053,
author = {Pogorelyy, M.V. and Elhanati, Y. and Marcou, Q. and Sycheva, A.L. and Komech, E.A. and Nazarov, V.I. and Britanova, Olga and Chudakov, Dmitriy and Mamedov, I.Z. and Lebedev, Y.B. and Mora, T. and Walczak, A.M.},
article_location = {SAN FRANCISCO},
article_number = {7},
doi = {http://dx.doi.org/10.1371/journal.pcbi.1005572},
keywords = {CONVERGENT RECOMBINATION; IDENTICAL-TWINS; PRENATAL ORIGIN; TCR; GENERATION; DIVERSITY; NAIVE; FREQUENCY; LEUKEMIA; IMMUNITY},
language = {eng},
issn = {1553-734X},
journal = {PLoS Computational Biology},
title = {Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires},
url = {http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005572&type=printable},
volume = {13},
year = {2017}
}
TY - JOUR
ID - 1411053
AU - Pogorelyy, M.V. - Elhanati, Y. - Marcou, Q. - Sycheva, A.L. - Komech, E.A. - Nazarov, V.I. - Britanova, Olga - Chudakov, Dmitriy - Mamedov, I.Z. - Lebedev, Y.B. - Mora, T. - Walczak, A.M.
PY - 2017
TI - Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
JF - PLoS Computational Biology
VL - 13
IS - 7
SP - nestránkováno
EP - nestránkováno
PB - PUBLIC LIBRARY SCIENCE
SN - 1553734X
KW - CONVERGENT RECOMBINATION
KW - IDENTICAL-TWINS
KW - PRENATAL ORIGIN
KW - TCR
KW - GENERATION
KW - DIVERSITY
KW - NAIVE
KW - FREQUENCY
KW - LEUKEMIA
KW - IMMUNITY
UR - http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005572&type=printable
L2 - http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005572&type=printable
N2 - The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset. By statistically analyzing deep sequencing T-cell repertoire data from twins, unrelated individuals of various ages, and cord blood, we show that T-cell clones generated before birth persist and maintain high abundances in adult organisms for decades, slowly decaying with age. Our results suggest that large, low-diversity public clones are created during pre-natal life, and survive over long periods, providing the basis of the public repertoire.
ER -
POGORELYY, M.V., Y. ELHANATI, Q. MARCOU, A.L. SYCHEVA, E.A. KOMECH, V.I. NAZAROV, Olga BRITANOVA, Dmitriy CHUDAKOV, I.Z. MAMEDOV, Y.B. LEBEDEV, T. MORA and A.M. WALCZAK. Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires. \textit{PLoS Computational Biology}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2017, vol.~13, No~7, p.~nestránkováno, 18 pp. ISSN~1553-734X. Available from: https://dx.doi.org/10.1371/journal.pcbi.1005572.
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