Persisting fetal clonotypes influence the structure and overlap
of adult human T cell receptor repertoires

J 2017

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires

POGORELYY, M.V., Y. ELHANATI, Q. MARCOU, A.L. SYCHEVA, E.A. KOMECH et. al.

Basic information

Original name

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires

Authors

POGORELYY, M.V. (643 Russian Federation), Y. ELHANATI (643 Russian Federation), Q. MARCOU (643 Russian Federation), A.L. SYCHEVA (643 Russian Federation), E.A. KOMECH (643 Russian Federation), V.I. NAZAROV (643 Russian Federation), Olga BRITANOVA (643 Russian Federation, belonging to the institution), Dmitriy CHUDAKOV (643 Russian Federation, guarantor, belonging to the institution), I.Z. MAMEDOV (643 Russian Federation), Y.B. LEBEDEV (643 Russian Federation), T. MORA (643 Russian Federation) and A.M. WALCZAK (643 Russian Federation)

Edition

PLoS Computational Biology, SAN FRANCISCO, PUBLIC LIBRARY SCIENCE, 2017, 1553-734X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10609 Biochemical research methods

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.955

RIV identification code

RIV/00216224:14740/17:00100346

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1371/journal.pcbi.1005572

UT WoS

000406619800010

Keywords in English

CONVERGENT RECOMBINATION; IDENTICAL-TWINS; PRENATAL ORIGIN; TCR; GENERATION; DIVERSITY; NAIVE; FREQUENCY; LEUKEMIA; IMMUNITY

Abstract

V originále

The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset. By statistically analyzing deep sequencing T-cell repertoire data from twins, unrelated individuals of various ages, and cord blood, we show that T-cell clones generated before birth persist and maintain high abundances in adult organisms for decades, slowly decaying with age. Our results suggest that large, low-diversity public clones are created during pre-natal life, and survive over long periods, providing the basis of the public repertoire.

Citovat

POGORELYY, M.V., Y. ELHANATI, Q. MARCOU, A.L. SYCHEVA, E.A. KOMECH, V.I. NAZAROV, Olga BRITANOVA, Dmitriy CHUDAKOV, I.Z. MAMEDOV, Y.B. LEBEDEV, T. MORA and A.M. WALCZAK. Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires. PLoS Computational Biology. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2017, vol. 13, No 7, p. nestránkováno, 18 pp. ISSN 1553-734X. Available from: https://dx.doi.org/10.1371/journal.pcbi.1005572.

@article{1411053,
   author = {Pogorelyy, M.V. and Elhanati, Y. and Marcou, Q. and Sycheva, A.L. and Komech, E.A. and Nazarov, V.I. and Britanova, Olga and Chudakov, Dmitriy and Mamedov, I.Z. and Lebedev, Y.B. and Mora, T. and Walczak, A.M.},
   article_location = {SAN FRANCISCO},
   article_number = {7},
   doi = {http://dx.doi.org/10.1371/journal.pcbi.1005572},
   keywords = {CONVERGENT RECOMBINATION; IDENTICAL-TWINS; PRENATAL ORIGIN; TCR; GENERATION; DIVERSITY; NAIVE; FREQUENCY; LEUKEMIA; IMMUNITY},
   language = {eng},
   issn = {1553-734X},
   journal = {PLoS Computational Biology},
   title = {Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires},
   url = {http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005572&type=printable},
   volume = {13},
   year = {2017}
}

TY  - JOUR
ID  - 1411053
AU  - Pogorelyy, M.V. - Elhanati, Y. - Marcou, Q. - Sycheva, A.L. - Komech, E.A. - Nazarov, V.I. - Britanova, Olga - Chudakov, Dmitriy - Mamedov, I.Z. - Lebedev, Y.B. - Mora, T. - Walczak, A.M.
PY  - 2017
TI  - Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
JF  - PLoS Computational Biology
VL  - 13
IS  - 7
SP  - nestránkováno
EP  - nestránkováno
PB  - PUBLIC LIBRARY SCIENCE
SN  - 1553734X
KW  - CONVERGENT RECOMBINATION
KW  - IDENTICAL-TWINS
KW  - PRENATAL ORIGIN
KW  - TCR
KW  - GENERATION
KW  - DIVERSITY
KW  - NAIVE
KW  - FREQUENCY
KW  - LEUKEMIA
KW  - IMMUNITY
UR  - http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005572&type=printable
L2  - http://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1005572&type=printable
N2  - The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset. By statistically analyzing deep sequencing T-cell repertoire data from twins, unrelated individuals of various ages, and cord blood, we show that T-cell clones generated before birth persist and maintain high abundances in adult organisms for decades, slowly decaying with age. Our results suggest that large, low-diversity public clones are created during pre-natal life, and survive over long periods, providing the basis of the public repertoire.
ER  -

POGORELYY, M.V., Y. ELHANATI, Q. MARCOU, A.L. SYCHEVA, E.A. KOMECH, V.I. NAZAROV, Olga BRITANOVA, Dmitriy CHUDAKOV, I.Z. MAMEDOV, Y.B. LEBEDEV, T. MORA and A.M. WALCZAK. Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires. \textit{PLoS Computational Biology}. SAN FRANCISCO: PUBLIC LIBRARY SCIENCE, 2017, vol.~13, No~7, p.~nestránkováno, 18 pp. ISSN~1553-734X. Available from: https://dx.doi.org/10.1371/journal.pcbi.1005572.

Detailed Information on Publication Record