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@article{1411207,
author = {Šafaříková, Eva and Švihálková Šindlerová, Lenka and Stříteský, Stanislav and Kubala, Lukáš and Vala, Martin and Weiter, Martin and Víteček, Jan},
article_number = {1.5.2018},
doi = {http://dx.doi.org/10.1016/j.snb.2017.12.108},
keywords = {TIPS-Pentacene; DPP(TBFu)2; P3HT; PEDOT:PSS; Biocompatibility; collagen IV; coating},
language = {eng},
issn = {0925-4005},
journal = {SENSORS AND ACTUATORS B: CHEMICAL},
title = {Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes},
url = {https://www.sciencedirect.com/science/article/pii/S0925400517324401},
volume = {260},
year = {2018}
}
TY - JOUR
ID - 1411207
AU - Šafaříková, Eva - Švihálková Šindlerová, Lenka - Stříteský, Stanislav - Kubala, Lukáš - Vala, Martin - Weiter, Martin - Víteček, Jan
PY - 2018
TI - Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes
JF - SENSORS AND ACTUATORS B: CHEMICAL
VL - 260
IS - 1.5.2018
SP - 418-425
EP - 418-425
PB - Elsevier Science
SN - 09254005
KW - TIPS-Pentacene
KW - DPP(TBFu)2
KW - P3HT
KW - PEDOT:PSS
KW - Biocompatibility
KW - collagen IV
KW - coating
UR - https://www.sciencedirect.com/science/article/pii/S0925400517324401
N2 - The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)2) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)2 and P3HT were stable but PEDOT:PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)2 and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)2, P3HT and PEDOT:PSS.
ER -
ŠAFAŘÍKOVÁ, Eva, Lenka ŠVIHÁLKOVÁ ŠINDLEROVÁ, Stanislav STŘÍTESKÝ, Lukáš KUBALA, Martin VALA, Martin WEITER a Jan VÍTEČEK. Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes. \textit{SENSORS AND ACTUATORS B: CHEMICAL}. Elsevier Science, 2018, roč.~260, 1.5.2018, s.~418-425. ISSN~0925-4005. Dostupné z: https://dx.doi.org/10.1016/j.snb.2017.12.108.
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