J 2018

Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes

ŠAFAŘÍKOVÁ, Eva, Lenka ŠVIHÁLKOVÁ ŠINDLEROVÁ, Stanislav STŘÍTESKÝ, Lukáš KUBALA, Martin VALA et. al.

Basic information

Original name

Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes

Authors

ŠAFAŘÍKOVÁ, Eva (203 Czech Republic, belonging to the institution), Lenka ŠVIHÁLKOVÁ ŠINDLEROVÁ (203 Czech Republic), Stanislav STŘÍTESKÝ (203 Czech Republic), Lukáš KUBALA (203 Czech Republic, belonging to the institution), Martin VALA (203 Czech Republic), Martin WEITER (203 Czech Republic) and Jan VÍTEČEK (203 Czech Republic, guarantor)

Edition

SENSORS AND ACTUATORS B: CHEMICAL, Elsevier Science, 2018, 0925-4005

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 6.393

RIV identification code

RIV/00216224:14310/18:00102399

Organization unit

Faculty of Science

DOI

UT WoS

000424884300050

Keywords in English

TIPS-Pentacene; DPP(TBFu)2; P3HT; PEDOT:PSS; Biocompatibility; collagen IV; coating

Tags

Tags

International impact, Reviewed
Změněno: 15/3/2019 13:30, Mgr. Bc. Lucie Nesvadbová

Abstract

V originále

The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)2) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)2 and P3HT were stable but PEDOT:PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)2 and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)2, P3HT and PEDOT:PSS.