| CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. Online. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, roč. 19, č. 1, s. nestránkováno, 14 s. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19010132. [citováno 2024-04-24] |
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@article{1411215,
author = {Chlapek, Petr and Sláviková, Viera and Mazánek, Pavel and Štěrba, Jaroslav and Veselská, Renata},
article_location = {Basel, Switzerland},
article_number = {1},
doi = {http://dx.doi.org/10.3390/ijms19010132},
keywords = {retinoids; cell differentiation; differentiation therapy; mechanisms of resistance},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids},
url = {http://www.mdpi.com/1422-0067/19/1/132},
volume = {19},
year = {2018}
}
TY - JOUR
ID - 1411215
AU - Chlapek, Petr - Sláviková, Viera - Mazánek, Pavel - Štěrba, Jaroslav - Veselská, Renata
PY - 2018
TI - Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids
JF - International Journal of Molecular Sciences
VL - 19
IS - 1
SP - nestránkováno
EP - nestránkováno
PB - MDPI AG
SN - 14220067
KW - retinoids
KW - cell differentiation
KW - differentiation therapy
KW - mechanisms of resistance
UR - http://www.mdpi.com/1422-0067/19/1/132
L2 - http://www.mdpi.com/1422-0067/19/1/132
N2 - In this review, we summarize the most common changes in retinoid metabolism and action that may affect the sensitivity of a tumor cell to treatment with retinoids. The availability of retinoids can be regulated by alterations in retinol metabolism or in retinoid intracellular transport, by degradation of retinoids or by their efflux from the cell. Retinoid effects on gene expression can be regulated via retinoid receptors or via other molecules in the transcriptional complex. Finally, the role of small-molecular-weight inhibitors of altered cell signaling pathways in overcoming the resistance to retinoids is also suggested.
ER -
CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. Online. \textit{International Journal of Molecular Sciences}. Basel, Switzerland: MDPI AG, 2018, roč.~19, č.~1, s.~nestránkováno, 14 s. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19010132. [citováno 2024-04-24]
|
