CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, vol. 19, No 1, p. nestránkováno, 14 pp. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms19010132. |
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@article{1411215, author = {Chlapek, Petr and Sláviková, Viera and Mazánek, Pavel and Štěrba, Jaroslav and Veselská, Renata}, article_location = {Basel, Switzerland}, article_number = {1}, doi = {http://dx.doi.org/10.3390/ijms19010132}, keywords = {retinoids; cell differentiation; differentiation therapy; mechanisms of resistance}, language = {eng}, issn = {1422-0067}, journal = {International Journal of Molecular Sciences}, title = {Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids}, url = {http://www.mdpi.com/1422-0067/19/1/132}, volume = {19}, year = {2018} }
TY - JOUR ID - 1411215 AU - Chlapek, Petr - Sláviková, Viera - Mazánek, Pavel - Štěrba, Jaroslav - Veselská, Renata PY - 2018 TI - Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids JF - International Journal of Molecular Sciences VL - 19 IS - 1 SP - nestránkováno EP - nestránkováno PB - MDPI AG SN - 14220067 KW - retinoids KW - cell differentiation KW - differentiation therapy KW - mechanisms of resistance UR - http://www.mdpi.com/1422-0067/19/1/132 L2 - http://www.mdpi.com/1422-0067/19/1/132 N2 - In this review, we summarize the most common changes in retinoid metabolism and action that may affect the sensitivity of a tumor cell to treatment with retinoids. The availability of retinoids can be regulated by alterations in retinol metabolism or in retinoid intracellular transport, by degradation of retinoids or by their efflux from the cell. Retinoid effects on gene expression can be regulated via retinoid receptors or via other molecules in the transcriptional complex. Finally, the role of small-molecular-weight inhibitors of altered cell signaling pathways in overcoming the resistance to retinoids is also suggested. ER -
CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. \textit{International Journal of Molecular Sciences}. Basel, Switzerland: MDPI AG, 2018, vol.~19, No~1, p.~nestránkováno, 14 pp. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms19010132.
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