Why Differentiation Therapy Sometimes Fails: Molecular
Mechanisms of Resistance to Retinoids

J 2018

Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids

CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA, Renata VESELSKÁ et. al.

Basic information

Original name

Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids

Authors

CHLAPEK, Petr (203 Czech Republic, belonging to the institution), Viera SLÁVIKOVÁ (703 Slovakia, belonging to the institution), Pavel MAZÁNEK (203 Czech Republic, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution) and Renata VESELSKÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

International Journal of Molecular Sciences, Basel, Switzerland, MDPI AG, 2018, 1422-0067

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.183

RIV identification code

RIV/00216224:14310/18:00106917

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.3390/ijms19010132

UT WoS

000424407200129

Keywords in English

retinoids; cell differentiation; differentiation therapy; mechanisms of resistance

Abstract

V originále

In this review, we summarize the most common changes in retinoid metabolism and action that may affect the sensitivity of a tumor cell to treatment with retinoids. The availability of retinoids can be regulated by alterations in retinol metabolism or in retinoid intracellular transport, by degradation of retinoids or by their efflux from the cell. Retinoid effects on gene expression can be regulated via retinoid receptors or via other molecules in the transcriptional complex. Finally, the role of small-molecular-weight inhibitors of altered cell signaling pathways in overcoming the resistance to retinoids is also suggested.

Links

LM2015090, research and development project

Name: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Acronym: CZECRIN)

Investor: Ministry of Education, Youth and Sports of the CR

NV15-34621A, research and development project

Name: Kandidátní biomarkery rezistence k retinoidům u dětí s vysoce rizikovými neuroblastomy

Citovat

CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, vol. 19, No 1, p. nestránkováno, 14 pp. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms19010132.

@article{1411215,
   author = {Chlapek, Petr and Sláviková, Viera and Mazánek, Pavel and Štěrba, Jaroslav and Veselská, Renata},
   article_location = {Basel, Switzerland},
   article_number = {1},
   doi = {http://dx.doi.org/10.3390/ijms19010132},
   keywords = {retinoids; cell differentiation; differentiation therapy; mechanisms of resistance},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids},
   url = {http://www.mdpi.com/1422-0067/19/1/132},
   volume = {19},
   year = {2018}
}

TY  - JOUR
ID  - 1411215
AU  - Chlapek, Petr - Sláviková, Viera - Mazánek, Pavel - Štěrba, Jaroslav - Veselská, Renata
PY  - 2018
TI  - Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids
JF  - International Journal of Molecular Sciences
VL  - 19
IS  - 1
SP  - nestránkováno
EP  - nestránkováno
PB  - MDPI AG
SN  - 14220067
KW  - retinoids
KW  - cell differentiation
KW  - differentiation therapy
KW  - mechanisms of resistance
UR  - http://www.mdpi.com/1422-0067/19/1/132
L2  - http://www.mdpi.com/1422-0067/19/1/132
N2  - In this review, we summarize the most common changes in retinoid metabolism and action that may affect the sensitivity of a tumor cell to treatment with retinoids. The availability of retinoids can be regulated by alterations in retinol metabolism or in retinoid intracellular transport, by degradation of retinoids or by their efflux from the cell. Retinoid effects on gene expression can be regulated via retinoid receptors or via other molecules in the transcriptional complex. Finally, the role of small-molecular-weight inhibitors of altered cell signaling pathways in overcoming the resistance to retinoids is also suggested.
ER  -

CHLAPEK, Petr, Viera SLÁVIKOVÁ, Pavel MAZÁNEK, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Why Differentiation Therapy Sometimes Fails: Molecular Mechanisms of Resistance to Retinoids. \textit{International Journal of Molecular Sciences}. Basel, Switzerland: MDPI AG, 2018, vol.~19, No~1, p.~nestránkováno, 14 pp. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms19010132.

Detailed Information on Publication Record