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@article{1411268,
author = {Plesník, Jiří and Šerý, Omar and Khan, Amira and Bielik, Peter and Khan, Naim Akhtar},
article_number = {4},
doi = {http://dx.doi.org/10.1017/S0007114517003981},
keywords = {CD36; fat taste; genetic; polymorphism; rs1527483},
language = {eng},
issn = {0007-1145},
journal = {British Journal of Nutrition},
title = {The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults.},
url = {https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/rs1527483-but-not-rs3212018-cd36-polymorphism-associates-with-linoleic-acid-detection-and-obesity-in-czech-young-adults/101BFA8F49E7ABAF805F75A1CA2F2A82},
volume = {119},
year = {2018}
}
TY - JOUR
ID - 1411268
AU - Plesník, Jiří - Šerý, Omar - Khan, Amira - Bielik, Peter - Khan, Naim Akhtar
PY - 2018
TI - The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults.
JF - British Journal of Nutrition
VL - 119
IS - 4
SP - 472-478
EP - 472-478
PB - Cambridge University Press
SN - 00071145
KW - CD36
KW - fat taste
KW - genetic
KW - polymorphism
KW - rs1527483
UR - https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/rs1527483-but-not-rs3212018-cd36-polymorphism-associates-with-linoleic-acid-detection-and-obesity-in-czech-young-adults/101BFA8F49E7ABAF805F75A1CA2F2A82
L2 - https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/rs1527483-but-not-rs3212018-cd36-polymorphism-associates-with-linoleic-acid-detection-and-obesity-in-czech-young-adults/101BFA8F49E7ABAF805F75A1CA2F2A82
N2 - Recent evidence has raised the possibility of the existence of a sixth taste modality – that is, taste for fat – which is mediated by lingual CD36 and plays a role in obesity. In the present study, we investigated the relationship between oro-sensory perception of linoleic acid (LA), two CD36 polymorphisms (rs1527483 and rs3212018), obesity parameters and craving habits for dietary lipids in young Czech adults. We observed that craving for dietary lipids was correlated with anthropometric parameters (P<0·05) and LA detection threshold (P=0·033). The participants with the CC genotype of the rs1527483 polymorphism had lower BMI (P=0·011), waist circumference (P=0·005), waist:height ratio (P=0·010) and higher sensitivity for LA (P=0·037) than the participants with the CT and TT genotypes. Interestingly, we did not observe any association between the rs3212018 polymorphism and the studied parameters. Moreover, we did not observe any mutation in exons 5 and 6 of the CD36 gene in these subjects. Finally, we can state that rs1527483 is associated with high body weight in young Czech subjects.
ER -
PLESNÍK, Jiří, Omar ŠERÝ, Amira KHAN, Peter BIELIK a Naim Akhtar KHAN. The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults. \textit{British Journal of Nutrition}. Cambridge University Press, 2018, roč.~119, č.~4, s.~472-478. ISSN~0007-1145. Dostupné z: https://dx.doi.org/10.1017/S0007114517003981.
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