FEDOTOVA, J., V. AKULOVA, S. PIVINA, J. DRAGASEK, M. CAPRNDA a Peter KRUŽLIAK. Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH. MADISON: E-CENTURY PUBLISHING CORP, roč. 9, č. 3, s. 1448-1459. ISSN 1943-8141. 2017.
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Základní údaje
Originální název Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens
Autoři FEDOTOVA, J. (643 Rusko), V. AKULOVA (643 Rusko), S. PIVINA (643 Rusko), J. DRAGASEK (703 Slovensko), M. CAPRNDA (703 Slovensko) a Peter KRUŽLIAK (703 Slovensko, garant, domácí).
Vydání AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, MADISON, E-CENTURY PUBLISHING CORP, 2017, 1943-8141.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30204 Oncology
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 3.061
Kód RIV RIV/00216224:14110/17:00100386
Organizační jednotka Lékařská fakulta
UT WoS 000399028800056
Klíčová slova anglicky Prenatal stress; anxiety; behavior; gonadectomy; testosterone; male offspring
Štítky EL OK
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Soňa Böhmová, učo 232884. Změněno: 11. 5. 2018 15:10.
Anotace
Gonadal hormones have been well-known to affect brain regions known to be involved in the modulation of mood and affective-related behavior. Prenatal stress might alter hypothalamic-pituitary-gonadal axis, it could be a target for development of affective-related disorders in male offspring. The present study was designed to examine an anxiety-like behavior in the adult male offspring with low levels of endogenous androgens delivered from pregnant dams exposed to prenatal stress from gestation day 15 to gestation day 19. The non-stressed and prenatally stressed intact, gonadectomized (GDX) and GDX male offspring treated with oil solvent or testosterone propionate (TP, 0.5 mg/kg, s.c., 14 days, once daily) were used in all experiments. Anxiety-like behavior was assessed in the elevated plus maze (EPM) and the open field test (OFT), respectively. Also, testosterone levels in the blood serum were measured in all experimental groups of offspring. Prenatally stressed GDX offspring demonstrated a significant decrease for time spent into the open arms and increase for time spent into the closed arms as compared to the non-stressed offspring. Administration of TP to the prenatally stressed GDX offspring resulted in a more markedly decrease of the time spent into the open arms and significantly raised the time spent into the closed arms as compared to the non-stressed GDX offspring treated with TP, non-stressed/prenatally stressed GDX offspring. Prenatally stressed GDX offspring showed a significant increase of crossing, rearing, grooming and defecation as compared to the prenatally stressed control offspring. On the contrary, administration of TP to the prenatally stressed GDX offspring significantly decreased crossing behavior, frequency of rearing and grooming behavior as compared to the non-stressed GDX offspring treated with TP, non-stressed/prenatally stressed GDX offspring. Prenatally stressed GDX offspring demonstrated a significant decrease of testosterone levels as compared to the non-stressed/prenatally stressed intact offspring, as well as non-stressed GDX offspring. Administration of TP significantly increased testosterone levels when prenatally stressed GDX offspring were compared with the prenatally stressed intact offspring, non-stressed/prenatally stressed GDX offspring. Thus, the results of the study clearly suggest that gonadectomy and TP supplementation profoundly changed an anxiety-related behavior in prenatally stressed male offspring in the EPM. Our current findings suggest that androgen deficiency in the prenatally stressed male offspring produces the high anxiety level and induces a marked anxious-like state. TP supplementation provokes development of profoundly anxious-like state in the prenatally stressed male offspring, Furthermore, this is the first study to show anxiogenic-like effect of TP administration on anxiety-related states in prenatally stressed male offspring with androgen deficiency.
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