Modifications of anxiety-like behavior in prenatally stressed
male offspring with imbalance of androgens

J 2017

Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens

FEDOTOVA, J., V. AKULOVA, S. PIVINA, J. DRAGASEK, M. CAPRNDA et. al.

Basic information

Original name

Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens

Authors

FEDOTOVA, J. (643 Russian Federation), V. AKULOVA (643 Russian Federation), S. PIVINA (643 Russian Federation), J. DRAGASEK (703 Slovakia), M. CAPRNDA (703 Slovakia) and Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution)

Edition

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, MADISON, E-CENTURY PUBLISHING CORP, 2017, 1943-8141

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.061

RIV identification code

RIV/00216224:14110/17:00100386

Organization unit

Faculty of Medicine

UT WoS

000399028800056

Keywords in English

Prenatal stress; anxiety; behavior; gonadectomy; testosterone; male offspring

Abstract

V originále

Gonadal hormones have been well-known to affect brain regions known to be involved in the modulation of mood and affective-related behavior. Prenatal stress might alter hypothalamic-pituitary-gonadal axis, it could be a target for development of affective-related disorders in male offspring. The present study was designed to examine an anxiety-like behavior in the adult male offspring with low levels of endogenous androgens delivered from pregnant dams exposed to prenatal stress from gestation day 15 to gestation day 19. The non-stressed and prenatally stressed intact, gonadectomized (GDX) and GDX male offspring treated with oil solvent or testosterone propionate (TP, 0.5 mg/kg, s.c., 14 days, once daily) were used in all experiments. Anxiety-like behavior was assessed in the elevated plus maze (EPM) and the open field test (OFT), respectively. Also, testosterone levels in the blood serum were measured in all experimental groups of offspring. Prenatally stressed GDX offspring demonstrated a significant decrease for time spent into the open arms and increase for time spent into the closed arms as compared to the non-stressed offspring. Administration of TP to the prenatally stressed GDX offspring resulted in a more markedly decrease of the time spent into the open arms and significantly raised the time spent into the closed arms as compared to the non-stressed GDX offspring treated with TP, non-stressed/prenatally stressed GDX offspring. Prenatally stressed GDX offspring showed a significant increase of crossing, rearing, grooming and defecation as compared to the prenatally stressed control offspring. On the contrary, administration of TP to the prenatally stressed GDX offspring significantly decreased crossing behavior, frequency of rearing and grooming behavior as compared to the non-stressed GDX offspring treated with TP, non-stressed/prenatally stressed GDX offspring. Prenatally stressed GDX offspring demonstrated a significant decrease of testosterone levels as compared to the non-stressed/prenatally stressed intact offspring, as well as non-stressed GDX offspring. Administration of TP significantly increased testosterone levels when prenatally stressed GDX offspring were compared with the prenatally stressed intact offspring, non-stressed/prenatally stressed GDX offspring. Thus, the results of the study clearly suggest that gonadectomy and TP supplementation profoundly changed an anxiety-related behavior in prenatally stressed male offspring in the EPM. Our current findings suggest that androgen deficiency in the prenatally stressed male offspring produces the high anxiety level and induces a marked anxious-like state. TP supplementation provokes development of profoundly anxious-like state in the prenatally stressed male offspring, Furthermore, this is the first study to show anxiogenic-like effect of TP administration on anxiety-related states in prenatally stressed male offspring with androgen deficiency.

Citovat

FEDOTOVA, J., V. AKULOVA, S. PIVINA, J. DRAGASEK, M. CAPRNDA and Peter KRUŽLIAK. Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH. MADISON: E-CENTURY PUBLISHING CORP, 2017, vol. 9, No 3, p. 1448-1459. ISSN 1943-8141.

@article{1411314,
   author = {Fedotova, J. and Akulova, V. and Pivina, S. and Dragasek, J. and Caprnda, M. and Kružliak, Peter},
   article_location = {MADISON},
   article_number = {3},
   keywords = {Prenatal stress; anxiety; behavior; gonadectomy; testosterone; male offspring},
   language = {eng},
   issn = {1943-8141},
   journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH},
   title = {Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens},
   volume = {9},
   year = {2017}
}

TY  - JOUR
ID  - 1411314
AU  - Fedotova, J. - Akulova, V. - Pivina, S. - Dragasek, J. - Caprnda, M. - Kružliak, Peter
PY  - 2017
TI  - Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens
JF  - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
VL  - 9
IS  - 3
SP  - 1448-1459
EP  - 1448-1459
PB  - E-CENTURY PUBLISHING CORP
SN  - 19438141
KW  - Prenatal stress
KW  - anxiety
KW  - behavior
KW  - gonadectomy
KW  - testosterone
KW  - male offspring
N2  - Gonadal hormones have been well-known to affect brain regions known to be involved in the modulation of mood and affective-related behavior. Prenatal stress might alter hypothalamic-pituitary-gonadal axis, it could be a target for development of affective-related disorders in male offspring. The present study was designed to examine an anxiety-like behavior in the adult male offspring with low levels of endogenous androgens delivered from pregnant dams exposed to prenatal stress from gestation day 15 to gestation day 19. The non-stressed and prenatally stressed intact, gonadectomized (GDX) and GDX male offspring treated with oil solvent or testosterone propionate (TP, 0.5 mg/kg, s.c., 14 days, once daily) were used in all experiments. Anxiety-like behavior was assessed in the elevated plus maze (EPM) and the open field test (OFT), respectively. Also, testosterone levels in the blood serum were measured in all experimental groups of offspring. Prenatally stressed GDX offspring demonstrated a significant decrease for time spent into the open arms and increase for time spent into the closed arms as compared to the non-stressed offspring. Administration of TP to the prenatally stressed GDX offspring resulted in a more markedly decrease of the time spent into the open arms and significantly raised the time spent into the closed arms as compared to the non-stressed GDX offspring treated with TP, non-stressed/prenatally stressed GDX offspring. Prenatally stressed GDX offspring showed a significant increase of crossing, rearing, grooming and defecation as compared to the prenatally stressed control offspring. On the contrary, administration of TP to the prenatally stressed GDX offspring significantly decreased crossing behavior, frequency of rearing and grooming behavior as compared to the non-stressed GDX offspring treated with TP, non-stressed/prenatally stressed GDX offspring. Prenatally stressed GDX offspring demonstrated a significant decrease of testosterone levels as compared to the non-stressed/prenatally stressed intact offspring, as well as non-stressed GDX offspring. Administration of TP significantly increased testosterone levels when prenatally stressed GDX offspring were compared with the prenatally stressed intact offspring, non-stressed/prenatally stressed GDX offspring. Thus, the results of the study clearly suggest that gonadectomy and TP supplementation profoundly changed an anxiety-related behavior in prenatally stressed male offspring in the EPM. Our current findings suggest that androgen deficiency in the prenatally stressed male offspring produces the high anxiety level and induces a marked anxious-like state. TP supplementation provokes development of profoundly anxious-like state in the prenatally stressed male offspring, Furthermore, this is the first study to show anxiogenic-like effect of TP administration on anxiety-related states in prenatally stressed male offspring with androgen deficiency.
ER  -

FEDOTOVA, J., V. AKULOVA, S. PIVINA, J. DRAGASEK, M. CAPRNDA and Peter KRUŽLIAK. Modifications of anxiety-like behavior in prenatally stressed male offspring with imbalance of androgens. \textit{AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}. MADISON: E-CENTURY PUBLISHING CORP, 2017, vol.~9, No~3, p.~1448-1459. ISSN~1943-8141.

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