High resolution IgH repertoire analysis reveals fetal liver as
the likely origin of life-long, innate B lymphopoiesis in
humans

J 2017

High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

ROY, A., Vojtěch BYSTRÝ, G. BOHN, K. GOUDEVENOU, Tomáš REIGL et. al.

Basic information

Original name

High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

Authors

ROY, A. (826 United Kingdom of Great Britain and Northern Ireland), Vojtěch BYSTRÝ (203 Czech Republic, belonging to the institution), G. BOHN (826 United Kingdom of Great Britain and Northern Ireland), K. GOUDEVENOU (826 United Kingdom of Great Britain and Northern Ireland), Tomáš REIGL (203 Czech Republic, belonging to the institution), M. PAPAIOANNOU (826 United Kingdom of Great Britain and Northern Ireland), Adam KREJČÍ (203 Czech Republic), S. O BYRNE (826 United Kingdom of Great Britain and Northern Ireland), A. CHAIDOS (826 United Kingdom of Great Britain and Northern Ireland), A. GRIONI (380 Italy), Nikos DARZENTAS (300 Greece, guarantor, belonging to the institution), I.A.G. ROBERTS (826 United Kingdom of Great Britain and Northern Ireland) and A. KARADIMITRIS (826 United Kingdom of Great Britain and Northern Ireland)

Edition

Clinical Immunology, San Diego, Academic Press Inc. 2017, 1521-6616

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.557

RIV identification code

RIV/00216224:14740/17:00095711

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.clim.2017.06.005

UT WoS

000414888600002

Keywords in English

Human; Fetal; IgH repertoire

Abstract

V originále

The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consistent with persisting fetal IgM+B cells being a source of natural IgM repertoire in adult life. Further, the origins of specific stereotypic IgM+B cell receptors associated with chronic lymphocytic leukemia, can be traced back to fetal B cell lymphopoiesis, suggesting that persisting fetal B cells can be subject to malignant transformation late in life. Overall, these novel data provide unique insights into the ontogeny of physiological and malignant B lymphopoiesis that spans the human lifetime. (C) 2017 The Authors. Published by Elsevier Inc.

Links

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

NV16-34272A, research and development project

Name: Encyklopedie CLL podskupin: unikátní znalostní databáze vybavená bioinformatickými nástroji použitelná v personalizované biomedicíně a klinické praxi

Citovat

ROY, A., Vojtěch BYSTRÝ, G. BOHN, K. GOUDEVENOU, Tomáš REIGL, M. PAPAIOANNOU, Adam KREJČÍ, S. O BYRNE, A. CHAIDOS, A. GRIONI, Nikos DARZENTAS, I.A.G. ROBERTS and A. KARADIMITRIS. High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans. Clinical Immunology. San Diego: Academic Press Inc., 2017, vol. 183, OCT, p. 8-16. ISSN 1521-6616. Available from: https://dx.doi.org/10.1016/j.clim.2017.06.005.

@article{1411378,
   author = {Roy, A. and Bystrý, Vojtěch and Bohn, G. and Goudevenou, K. and Reigl, Tomáš and Papaioannou, M. and Krejčí, Adam and O Byrne, S. and Chaidos, A. and Grioni, A. and Darzentas, Nikos and Roberts, I.A.G. and Karadimitris, A.},
   article_location = {San Diego},
   article_number = {OCT},
   doi = {http://dx.doi.org/10.1016/j.clim.2017.06.005},
   keywords = {Human; Fetal; IgH repertoire},
   language = {eng},
   issn = {1521-6616},
   journal = {Clinical Immunology},
   title = {High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans},
   url = {https://www.sciencedirect.com/science/article/pii/S1521661617303686?via%3Dihub},
   volume = {183},
   year = {2017}
}

TY  - JOUR
ID  - 1411378
AU  - Roy, A. - Bystrý, Vojtěch - Bohn, G. - Goudevenou, K. - Reigl, Tomáš - Papaioannou, M. - Krejčí, Adam - O Byrne, S. - Chaidos, A. - Grioni, A. - Darzentas, Nikos - Roberts, I.A.G. - Karadimitris, A.
PY  - 2017
TI  - High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans
JF  - Clinical Immunology
VL  - 183
IS  - OCT
SP  - 8-16
EP  - 8-16
PB  - Academic Press Inc.
SN  - 15216616
KW  - Human
KW  - Fetal
KW  - IgH repertoire
UR  - https://www.sciencedirect.com/science/article/pii/S1521661617303686?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S1521661617303686?via%3Dihub
N2  - The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consistent with persisting fetal IgM+B cells being a source of natural IgM repertoire in adult life. Further, the origins of specific stereotypic IgM+B cell receptors associated with chronic lymphocytic leukemia, can be traced back to fetal B cell lymphopoiesis, suggesting that persisting fetal B cells can be subject to malignant transformation late in life. Overall, these novel data provide unique insights into the ontogeny of physiological and malignant B lymphopoiesis that spans the human lifetime. (C) 2017 The Authors. Published by Elsevier Inc.
ER  -

ROY, A., Vojtěch BYSTRÝ, G. BOHN, K. GOUDEVENOU, Tomáš REIGL, M. PAPAIOANNOU, Adam KREJČÍ, S. O BYRNE, A. CHAIDOS, A. GRIONI, Nikos DARZENTAS, I.A.G. ROBERTS and A. KARADIMITRIS. High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans. \textit{Clinical Immunology}. San Diego: Academic Press Inc., 2017, vol.~183, OCT, p.~8-16. ISSN~1521-6616. Available from: https://dx.doi.org/10.1016/j.clim.2017.06.005.

Detailed Information on Publication Record