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@article{1411378,
author = {Roy, A. and Bystrý, Vojtěch and Bohn, G. and Goudevenou, K. and Reigl, Tomáš and Papaioannou, M. and Krejčí, Adam and O Byrne, S. and Chaidos, A. and Grioni, A. and Darzentas, Nikos and Roberts, I.A.G. and Karadimitris, A.},
article_location = {San Diego},
article_number = {OCT},
doi = {http://dx.doi.org/10.1016/j.clim.2017.06.005},
keywords = {Human; Fetal; IgH repertoire},
language = {eng},
issn = {1521-6616},
journal = {Clinical Immunology},
title = {High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans},
url = {https://www.sciencedirect.com/science/article/pii/S1521661617303686?via%3Dihub},
volume = {183},
year = {2017}
}
TY - JOUR
ID - 1411378
AU - Roy, A. - Bystrý, Vojtěch - Bohn, G. - Goudevenou, K. - Reigl, Tomáš - Papaioannou, M. - Krejčí, Adam - O Byrne, S. - Chaidos, A. - Grioni, A. - Darzentas, Nikos - Roberts, I.A.G. - Karadimitris, A.
PY - 2017
TI - High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans
JF - Clinical Immunology
VL - 183
IS - OCT
SP - 8-16
EP - 8-16
PB - Academic Press Inc.
SN - 15216616
KW - Human
KW - Fetal
KW - IgH repertoire
UR - https://www.sciencedirect.com/science/article/pii/S1521661617303686?via%3Dihub
L2 - https://www.sciencedirect.com/science/article/pii/S1521661617303686?via%3Dihub
N2 - The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consistent with persisting fetal IgM+B cells being a source of natural IgM repertoire in adult life. Further, the origins of specific stereotypic IgM+B cell receptors associated with chronic lymphocytic leukemia, can be traced back to fetal B cell lymphopoiesis, suggesting that persisting fetal B cells can be subject to malignant transformation late in life. Overall, these novel data provide unique insights into the ontogeny of physiological and malignant B lymphopoiesis that spans the human lifetime. (C) 2017 The Authors. Published by Elsevier Inc.
ER -
ROY, A., Vojtěch BYSTRÝ, G. BOHN, K. GOUDEVENOU, Tomáš REIGL, M. PAPAIOANNOU, Adam KREJČÍ, S. O BYRNE, A. CHAIDOS, A. GRIONI, Nikos DARZENTAS, I.A.G. ROBERTS and A. KARADIMITRIS. High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans. \textit{Clinical Immunology}. San Diego: Academic Press Inc., 2017, vol.~183, OCT, p.~8-16. ISSN~1521-6616. Available from: https://dx.doi.org/10.1016/j.clim.2017.06.005.
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