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@article{1411805,
author = {Hot, B. and Valnohova, J. and Arthofer, E. and Simon, K. and Shin, J. and Uhlen, M. and Kostenis, E. and Mulder, J. and Schulte, Gunnar},
article_location = {NEW YORK},
article_number = {April},
doi = {http://dx.doi.org/10.1016/j.cellsig.2017.01.023},
keywords = {WNT; FZD; GPCR; Endothelial cell; Angiogenesis; GNA13; YAP/PAZ},
language = {eng},
issn = {0898-6568},
journal = {Cellular Signalling},
title = {FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis},
volume = {32},
year = {2017}
}
TY - JOUR
ID - 1411805
AU - Hot, B. - Valnohova, J. - Arthofer, E. - Simon, K. - Shin, J. - Uhlen, M. - Kostenis, E. - Mulder, J. - Schulte, Gunnar
PY - 2017
TI - FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis
JF - Cellular Signalling
VL - 32
IS - April
SP - 93-103
EP - 93-103
PB - ELSEVIER SCIENCE INC
SN - 08986568
KW - WNT
KW - FZD
KW - GPCR
KW - Endothelial cell
KW - Angiogenesis
KW - GNA13
KW - YAP/PAZ
N2 - Among the 10 Frizzled (FZD) isoforms belonging to the Class F of G protein-coupled receptors (GPCRs), FZD(10) remains the most enigmatic. FZD10 shows homology to FZD(4) and FZD(9) and was previously implicated in both beta-catenin-dependent and-independent signalling. In normal tissue, FZD(10) levels are generally very low; however, its upregulation in synovial carcinoma has attracted some attention for therapy. Our findings identify FZD(10), as a receptor interacting with and signalling through the heterotrimeric G protein G alpha(13) but not G alpha(12), G alpha(i1,) G alpha(oA), G alpha(s), or G alpha(q). Stimulation with the FZD agonist WNT induced the dissociation of the G alpha(13) protein from FZD(10), and led to global G alpha(12/13)-dependent cell changes assessed by dynamic mass redistribution measurements. Furthermore, we show that FZD(10) mediates G alpha(12/13) activation-dependent induction of YAP/TAZ transcriptional activity. In addition, we show a distinct expression of FZD(10) in embryonic CNS endothelial cells at E11.5-E14.5. Given the well-known importance of G alpha(13) signalling for the development of the vascular system, the selective expression of FZD(10) in brain vascular endothelial cells points at a potential role of FZD(10)-G alpha(13) signalling in CNS angiogenesis. (C) 2017 Elsevier Inc. All rights reserved.
ER -
HOT, B., J. VALNOHOVA, E. ARTHOFER, K. SIMON, J. SHIN, M. UHLEN, E. KOSTENIS, J. MULDER a Gunnar SCHULTE. FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis. Online. \textit{Cellular Signalling}. NEW YORK: ELSEVIER SCIENCE INC, 2017, roč.~32, April, s.~93-103. ISSN~0898-6568. Dostupné z: https://dx.doi.org/10.1016/j.cellsig.2017.01.023. [citováno 2024-04-24]
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