HOT, B., J. VALNOHOVA, E. ARTHOFER, K. SIMON, J. SHIN, M. UHLEN, E. KOSTENIS, J. MULDER and Gunnar SCHULTE. FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis. Online. Cellular Signalling. NEW YORK: ELSEVIER SCIENCE INC, 2017, vol. 32, April, p. 93-103. ISSN 0898-6568. Available from: https://dx.doi.org/10.1016/j.cellsig.2017.01.023. [citováno 2024-04-24]
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Basic information
Original name FZD(10)-G alpha(13) signalling axis points to a role of FZD(10) in CNS angiogenesis
Authors HOT, B. (752 Sweden), J. VALNOHOVA (203 Czech Republic), E. ARTHOFER (840 United States of America), K. SIMON (276 Germany), J. SHIN (752 Sweden), M. UHLEN (752 Sweden), E. KOSTENIS (276 Germany), J. MULDER (752 Sweden) and Gunnar SCHULTE (276 Germany, guarantor, belonging to the institution)
Edition Cellular Signalling, NEW YORK, ELSEVIER SCIENCE INC, 2017, 0898-6568.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.487
RIV identification code RIV/00216224:14310/17:00100422
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.cellsig.2017.01.023
UT WoS 000395953400010
Keywords in English WNT; FZD; GPCR; Endothelial cell; Angiogenesis; GNA13; YAP/PAZ
Tags NZ, rivok
Tags International impact, Reviewed
Changed by Changed by: Ing. Nicole Zrilić, učo 240776. Changed: 4/4/2018 09:21.
Abstract
Among the 10 Frizzled (FZD) isoforms belonging to the Class F of G protein-coupled receptors (GPCRs), FZD(10) remains the most enigmatic. FZD10 shows homology to FZD(4) and FZD(9) and was previously implicated in both beta-catenin-dependent and-independent signalling. In normal tissue, FZD(10) levels are generally very low; however, its upregulation in synovial carcinoma has attracted some attention for therapy. Our findings identify FZD(10), as a receptor interacting with and signalling through the heterotrimeric G protein G alpha(13) but not G alpha(12), G alpha(i1,) G alpha(oA), G alpha(s), or G alpha(q). Stimulation with the FZD agonist WNT induced the dissociation of the G alpha(13) protein from FZD(10), and led to global G alpha(12/13)-dependent cell changes assessed by dynamic mass redistribution measurements. Furthermore, we show that FZD(10) mediates G alpha(12/13) activation-dependent induction of YAP/TAZ transcriptional activity. In addition, we show a distinct expression of FZD(10) in embryonic CNS endothelial cells at E11.5-E14.5. Given the well-known importance of G alpha(13) signalling for the development of the vascular system, the selective expression of FZD(10) in brain vascular endothelial cells points at a potential role of FZD(10)-G alpha(13) signalling in CNS angiogenesis. (C) 2017 Elsevier Inc. All rights reserved.
Links
EE2.3.20.0180, research and development projectName: Spolupráce mezi Masarykovou univerzitou a Karolinska Institutet, Stockholm na poli biomedicíny
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