| KREMSEROVÁ, Silvie, Tomáš PEREČKO, Karel SOUČEK, A. KLINKE, S. BALDUS, J.P. EISERICH and Lukáš KUBALA. Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation. Oxidative Medicine and Cellular Longevity. London: HINDAWI LTD, 2016, vol. 2016, No 1, p. nestránkováno, 13 pp. ISSN 1942-0900. Available from: https://dx.doi.org/10.1155/2016/5219056. |
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@article{1411870,
author = {Kremserová, Silvie and Perečko, Tomáš and Souček, Karel and Klinke, A. and Baldus, S. and Eiserich, J.P. and Kubala, Lukáš},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1155/2016/5219056},
keywords = {NITROTYROSINE FORMATION; AIRWAY INFLAMMATION; MOUSE NEUTROPHILS; APOPTOSIS; ACTIVATION; ACID; RESOLUTION; IMMUNITY; DISEASE; INJURY},
language = {eng},
issn = {1942-0900},
journal = {Oxidative Medicine and Cellular Longevity},
title = {Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation},
volume = {2016},
year = {2016}
}
TY - JOUR
ID - 1411870
AU - Kremserová, Silvie - Perečko, Tomáš - Souček, Karel - Klinke, A. - Baldus, S. - Eiserich, J.P. - Kubala, Lukáš
PY - 2016
TI - Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation
JF - Oxidative Medicine and Cellular Longevity
VL - 2016
IS - 1
SP - nestránkováno
EP - nestránkováno
PB - HINDAWI LTD
SN - 19420900
KW - NITROTYROSINE FORMATION
KW - AIRWAY INFLAMMATION
KW - MOUSE NEUTROPHILS
KW - APOPTOSIS
KW - ACTIVATION
KW - ACID
KW - RESOLUTION
KW - IMMUNITY
KW - DISEASE
KW - INJURY
N2 - Systemic inflammation accompanying diseases such as sepsis affects primarily lungs and induces their failure. This remains the most common cause of sepsis induced mortality. While neutrophils play a key role in pulmonary failure, the mechanisms remain incompletely characterized. We report that myeloperoxidase (MPO), abundant enzyme in neutrophil granules, modulates the course of acute pulmonary inflammatory responses induced by intranasal application of lipopolysaccharide. MPO deficient mice had significantly increased numbers of airway infiltrated neutrophils compared to wild-type mice during the whole course of lung inflammation. This was accompanied by higher levels of RANTES in bronchoalveolar lavage fluid from the MPO deficient mice. Other markers of lung injury and inflammation, which contribute to recruitment of neutrophils into the inflamed lungs, including total protein and other selected proinflammatory cytokines did not significantly differ in bronchoalveolar lavage fluid from the wildtype and the MPO deficient mice. Interestingly, MPO deficient neutrophils revealed a decreased rate of cell death characterized by phosphatidylserine surface expression. Collectively, the importance of MPO in regulation of pulmonary inflammation, independent of its putative microbicidal functions, can be potentially linked to MPO ability to modulate the life span of neutrophils and to affect accumulation of chemotactic factors at the inflammatory site.
ER -
KREMSEROVÁ, Silvie, Tomáš PEREČKO, Karel SOUČEK, A. KLINKE, S. BALDUS, J.P. EISERICH and Lukáš KUBALA. Lung Neutrophilia in Myeloperoxidase Deficient Mice during the Course of Acute Pulmonary Inflammation. \textit{Oxidative Medicine and Cellular Longevity}. London: HINDAWI LTD, 2016, vol.~2016, No~1, p.~nestránkováno, 13 pp. ISSN~1942-0900. Available from: https://dx.doi.org/10.1155/2016/5219056.
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