MicroRNAs as a tool to aid stratification of colorectal cancer
patients and to guide therapy

J 2017

MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy

GOBLIRSCH, M., G. RICHTIG, Ondřej SLABÝ, I. BERINDAN-NEAGOE, A. GERGER et. al.

Basic information

Original name

MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy

Authors

GOBLIRSCH, M. (40 Austria), G. RICHTIG (40 Austria), Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution), I. BERINDAN-NEAGOE (642 Romania), A. GERGER (40 Austria) and M. PICHLER (40 Austria)

Edition

PHARMACOGENOMICS, LONDON, FUTURE MEDICINE LTD, 2017, 1462-2416

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.302

RIV identification code

RIV/00216224:14740/17:00100447

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.2217/pgs-2017-0004

UT WoS

000405697300010

Keywords in English

colorectal cancer; diagnosis; microRNAs; treatment

Abstract

V originále

Colorectal cancer is a common type of malignant disease with high rates of morbidity and mortality. Although treatment options have been expanded over the last years, the mainstay of curative treatment remains surgical removal of the tumor-bearing organ. Systemic treatment options include classic cytotoxic drugs as well as some biological agents. Noncoding RNAs are an evolving field in cancer diagnosis, prognosis and possible treatment. Noncoding miRNAs are small molecules with huge impact on gene expression. They have been a substantial part of cancer research for more than a decade. In this review article, the current knowledge of miRNAs and colorectal cancer diagnosis, prognosis and novel or evolving therapeutic concepts are discussed. Examples of how miRNAs might change the management of the disease will be described.

Citovat

GOBLIRSCH, M., G. RICHTIG, Ondřej SLABÝ, I. BERINDAN-NEAGOE, A. GERGER and M. PICHLER. MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy. PHARMACOGENOMICS. LONDON: FUTURE MEDICINE LTD, 2017, vol. 18, No 10, p. 1027-1038. ISSN 1462-2416. Available from: https://dx.doi.org/10.2217/pgs-2017-0004.

@article{1411975,
   author = {Goblirsch, M. and Richtig, G. and Slabý, Ondřej and BerindanandNeagoe, I. and Gerger, A. and Pichler, M.},
   article_location = {LONDON},
   article_number = {10},
   doi = {http://dx.doi.org/10.2217/pgs-2017-0004},
   keywords = {colorectal cancer; diagnosis; microRNAs; treatment},
   language = {eng},
   issn = {1462-2416},
   journal = {PHARMACOGENOMICS},
   title = {MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy},
   url = {https://www.futuremedicine.com/doi/10.2217/pgs-2017-0004},
   volume = {18},
   year = {2017}
}

TY  - JOUR
ID  - 1411975
AU  - Goblirsch, M. - Richtig, G. - Slabý, Ondřej - Berindan-Neagoe, I. - Gerger, A. - Pichler, M.
PY  - 2017
TI  - MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy
JF  - PHARMACOGENOMICS
VL  - 18
IS  - 10
SP  - 1027-1038
EP  - 1027-1038
PB  - FUTURE MEDICINE LTD
SN  - 14622416
KW  - colorectal cancer
KW  - diagnosis
KW  - microRNAs
KW  - treatment
UR  - https://www.futuremedicine.com/doi/10.2217/pgs-2017-0004
L2  - https://www.futuremedicine.com/doi/10.2217/pgs-2017-0004
N2  - Colorectal cancer is a common type of malignant disease with high rates of morbidity and mortality. Although treatment options have been expanded over the last years, the mainstay of curative treatment remains surgical removal of the tumor-bearing organ. Systemic treatment options include classic cytotoxic drugs as well as some biological agents. Noncoding RNAs are an evolving field in cancer diagnosis, prognosis and possible treatment. Noncoding miRNAs are small molecules with huge impact on gene expression. They have been a substantial part of cancer research for more than a decade. In this review article, the current knowledge of miRNAs and colorectal cancer diagnosis, prognosis and novel or evolving therapeutic concepts are discussed. Examples of how miRNAs might change the management of the disease will be described.
ER  -

GOBLIRSCH, M., G. RICHTIG, Ondřej SLABÝ, I. BERINDAN-NEAGOE, A. GERGER and M. PICHLER. MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy. \textit{PHARMACOGENOMICS}. LONDON: FUTURE MEDICINE LTD, 2017, vol.~18, No~10, p.~1027-1038. ISSN~1462-2416. Available from: https://dx.doi.org/10.2217/pgs-2017-0004.

Detailed Information on Publication Record