Cardiovagal and adrenergic function tests in unilateral carotid artery stenosis patients-a Valsalva manoeuvre tool to show an autonomic dysfunction?

SVIGELJ, Viktor, Matjaž SINKOVEC, Viktor AVBELJ, Roman TROBEC, Ludovit GASPAR, Daniel PETROVIC and Peter KRUŽLIAK. Cardiovagal and adrenergic function tests in unilateral carotid artery stenosis patients-a Valsalva manoeuvre tool to show an autonomic dysfunction? Wiener klinische Wochenschrift. Vídeň: SPRINGER WIEN, 2016, vol. 128, 13-14, p. 504-512. ISSN 0043-5325. Available from: https://dx.doi.org/10.1007/s00508-016-0980-2.

Basic information

Original name

Cardiovagal and adrenergic function tests in unilateral carotid artery stenosis patients-a Valsalva manoeuvre tool to show an autonomic dysfunction?

Authors

SVIGELJ, Viktor (705 Slovenia), Matjaž SINKOVEC (705 Slovenia), Viktor AVBELJ (705 Slovenia), Roman TROBEC (705 Slovenia), Ludovit GASPAR (703 Slovakia), Daniel PETROVIC (705 Slovenia) and Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution)

Edition

Wiener klinische Wochenschrift, Vídeň, SPRINGER WIEN, 2016, 0043-5325

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30218 General and internal medicine

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.974

RIV identification code

RIV/00216224:14110/16:00100474

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00508-016-0980-2

UT WoS

000380123500005

Keywords in English

Autonomic nervous system disorders; Baroreflex; Valsalva manoeuvre; Carotid artery stenosis; Carotid sinus

Tags

EL OK

Tags

International impact, Reviewed

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Abstract

V originále

The stability of an arterial baroreflex depends also upon the integrity of the afferent limb. For its quantification, we can use a noninvasive test such as baroreceptor sensitivity estimation during Valsalva manoeuvre. The aim of this study was to evaluate potential autonomic dysfunction in patients with unilateral severe carotid disease and compare the results to the results obtained from an age and gender matched group of healthy volunteers. We evaluated dynamic changes during Valsalva manoeuvre (Valsalva ratio, cardiovagal and adrenergic baroreceptor sensitivity, sympathetic indexes and its dynamic ranges) in 41 patients (29 males; 62.9 +/- 7.4 years) and compared the results to results obtained from volunteers (62.8 +/- 7.0 years). Valsalva ratio between the patients and control group revealed no significant difference, as well as cardiovagal and adrenergic baroreceptor sensitivity. Sympathetic indexes, except for sympathetic index 2, reflecting the sympathetic vasoconstrictor baroreceptor response in late phase 2 of Valsalva manoeuvre (7.1 +/- 13.1 mmHg in patients vs. 11.4 +/- 10.2 mmHg in control group; p = 0.012) showed no significant differences between the studied groups. The most prominent dynamic range between the groups was within the sympathetic index 2. With some Valsalva manoeuvre test results, we were not able to show severe autonomic dysfunction in unilateral severe carotid stenosis patients except for lower vasoconstriction response within the late phase 2 of the manoeuvre.