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@article{1412148,
author = {Langowski, L. and Wabnik, K. and Li, H.J. and Vanneste, S. and Naramoto, S. and Tanaka, H. and Friml, Jiří},
article_location = {LONDON},
article_number = {JUL},
doi = {http://dx.doi.org/10.1038/celldisc.2016.18},
keywords = {protein trafficking; polar recycling; polar secretion; lateral diffusion; protein clustering; protein dynamics modeling},
language = {eng},
issn = {2056-5968},
journal = {CELL DISCOVERY},
title = {Cellular mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells},
url = {https://www.nature.com/articles/celldisc201618},
volume = {2},
year = {2016}
}
TY - JOUR
ID - 1412148
AU - Langowski, L. - Wabnik, K. - Li, H.J. - Vanneste, S. - Naramoto, S. - Tanaka, H. - Friml, Jiří
PY - 2016
TI - Cellular mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells
JF - CELL DISCOVERY
VL - 2
IS - JUL
SP - 16018
EP - 16018
PB - NATURE PUBLISHING GROUP
SN - 20565968
KW - protein trafficking
KW - polar recycling
KW - polar secretion
KW - lateral diffusion
KW - protein clustering
KW - protein dynamics modeling
UR - https://www.nature.com/articles/celldisc201618
L2 - https://www.nature.com/articles/celldisc201618
N2 - The asymmetric localization of proteins in the plasma membrane domains of eukaryotic cells is a fundamental manifestation of cell polarity that is central to multicellular organization and developmental patterning. In plants, the mechanisms underlying the polar localization of cargo proteins are still largely unknown and appear to be fundamentally distinct from those operating in mammals. Here, we present a systematic, quantitative comparative analysis of the polar delivery and subcellular localization of proteins that characterize distinct polar plasma membrane domains in plant cells. The combination of microscopic analyses and computational modeling revealed a mechanistic framework common to diverse polar cargos and underlying the establishment and maintenance of apical, basal, and lateral polar domains in plant cells. This mechanism depends on the polar secretion, constitutive endocytic recycling, and restricted lateral diffusion of cargos within the plasma membrane. Moreover, our observations suggest that polar cargo distribution involves the individual protein potential to form clusters within the plasma membrane and interact with the extracellular matrix. Our observations provide insights into the shared cellular mechanisms of polar cargo delivery and polarity maintenance in plant cells.
ER -
LANGOWSKI, L., K. WABNIK, H.J. LI, S. VANNESTE, S. NARAMOTO, H. TANAKA and Jiří FRIML. Cellular mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells. \textit{CELL DISCOVERY}. LONDON: NATURE PUBLISHING GROUP, 2016, vol.~2, JUL, p.~16018-16035. ISSN~2056-5968. Available from: https://dx.doi.org/10.1038/celldisc.2016.18.
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