TRPV currents and their role in the nociception and
neuroplasticity

J 2016

TRPV currents and their role in the nociception and neuroplasticity

SATHEESH, Noothan Jyothi, Yoshio UEHARA, Julia FEDOTOVA, Miroslav POHANKA, Dietrich BUSSELBERG et. al.

Basic information

Original name

TRPV currents and their role in the nociception and neuroplasticity

Authors

SATHEESH, Noothan Jyothi (634 Qatar), Yoshio UEHARA (392 Japan), Julia FEDOTOVA (643 Russian Federation), Miroslav POHANKA (203 Czech Republic), Dietrich BUSSELBERG (634 Qatar) and Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution)

Edition

NEUROPEPTIDES, EDINBURGH, CHURCHILL LIVINGSTONE, 2016, 0143-4179

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.486

RIV identification code

RIV/00216224:14110/16:00100475

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.npep.2016.01.003

UT WoS

000378193100001

Keywords in English

TRPV receptors; Currents; Nociception; Neuroplasticity; Therapy

Abstract

V originále

Transient receptor potential channels sensitive to vanilloids (TRPVs) are group of ion channels which are sensitive to various tissue damaging signals and their activation is generally perceived as pain. Therefore, they are generally named as nociceptors. Understanding their activation and function as well as their interaction with intracellular pathways is crucial for the development of pharmacological interference in order to"reduce pain perception. The current review summarizes basic facts in regard to TRPV and discusses their relevance in the sensing of (pain-) signals and their intracellular processing, focussing on their modulation of the intracellular calcium ([Ca2+](i)) signal. Furthermore we discuss the basic mechanisms how the modification of [Ca2+](i) through TRPV might induce long-term-potentiation (LTP) or long-term- depression (LTD) and from "memories" of pain. Understanding of these mechanisms is needed to localize the best point of interference for pharmacological treatment. Therefore, high attention is given to highlight physiological and pathological processes and their interaction with significant modulators and their roles in neuroplasticity and pain modulation. (C) 2016 Elsevier Ltd. All rights reserved.

Citovat

SATHEESH, Noothan Jyothi, Yoshio UEHARA, Julia FEDOTOVA, Miroslav POHANKA, Dietrich BUSSELBERG and Peter KRUŽLIAK. TRPV currents and their role in the nociception and neuroplasticity. NEUROPEPTIDES. EDINBURGH: CHURCHILL LIVINGSTONE, 2016, vol. 57, JUN 2016, p. 1-8. ISSN 0143-4179. Available from: https://dx.doi.org/10.1016/j.npep.2016.01.003.

@article{1412150,
   author = {Satheesh, Noothan Jyothi and Uehara, Yoshio and Fedotova, Julia and Pohanka, Miroslav and Busselberg, Dietrich and Kružliak, Peter},
   article_location = {EDINBURGH},
   article_number = {JUN 2016},
   doi = {http://dx.doi.org/10.1016/j.npep.2016.01.003},
   keywords = {TRPV receptors; Currents; Nociception; Neuroplasticity; Therapy},
   language = {eng},
   issn = {0143-4179},
   journal = {NEUROPEPTIDES},
   title = {TRPV currents and their role in the nociception and neuroplasticity},
   volume = {57},
   year = {2016}
}

TY  - JOUR
ID  - 1412150
AU  - Satheesh, Noothan Jyothi - Uehara, Yoshio - Fedotova, Julia - Pohanka, Miroslav - Busselberg, Dietrich - Kružliak, Peter
PY  - 2016
TI  - TRPV currents and their role in the nociception and neuroplasticity
JF  - NEUROPEPTIDES
VL  - 57
IS  - JUN 2016
SP  - 1-8
EP  - 1-8
PB  - CHURCHILL LIVINGSTONE
SN  - 01434179
KW  - TRPV receptors
KW  - Currents
KW  - Nociception
KW  - Neuroplasticity
KW  - Therapy
N2  - Transient receptor potential channels sensitive to vanilloids (TRPVs) are group of ion channels which are sensitive to various tissue damaging signals and their activation is generally perceived as pain. Therefore, they are generally named as nociceptors. Understanding their activation and function as well as their interaction with intracellular pathways is crucial for the development of pharmacological interference in order to"reduce pain perception. The current review summarizes basic facts in regard to TRPV and discusses their relevance in the sensing of (pain-) signals and their intracellular processing, focussing on their modulation of the intracellular calcium ([Ca2+](i)) signal. Furthermore we discuss the basic mechanisms how the modification of [Ca2+](i) through TRPV might induce long-term-potentiation (LTP) or long-term- depression (LTD) and from "memories" of pain. Understanding of these mechanisms is needed to localize the best point of interference for pharmacological treatment. Therefore, high attention is given to highlight physiological and pathological processes and their interaction with significant modulators and their roles in neuroplasticity and pain modulation. (C) 2016 Elsevier Ltd. All rights reserved.
ER  -

SATHEESH, Noothan Jyothi, Yoshio UEHARA, Julia FEDOTOVA, Miroslav POHANKA, Dietrich BUSSELBERG and Peter KRUŽLIAK. TRPV currents and their role in the nociception and neuroplasticity. \textit{NEUROPEPTIDES}. EDINBURGH: CHURCHILL LIVINGSTONE, 2016, vol.~57, JUN 2016, p.~1-8. ISSN~0143-4179. Available from: https://dx.doi.org/10.1016/j.npep.2016.01.003.

Detailed Information on Publication Record