| SAKUYAMA, Hiroe, Minami KATOH, Honoka WAKABAYASHI, Anthony ZULLI, Peter KRUŽLIAK and Yoshio UEHARA. Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood. Journal of Biomedical Science. BioMed website: BioMed Central, London, England, 2016, vol. 23, JAN 20 2016, p. 1-9. ISSN 1021-7770. Available from: https://dx.doi.org/10.1186/s12929-016-0233-8. |
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@article{1412160,
author = {Sakuyama, Hiroe and Katoh, Minami and Wakabayashi, Honoka and Zulli, Anthony and Kružliak, Peter and Uehara, Yoshio},
article_location = {BioMed website},
article_number = {JAN 20 2016},
doi = {http://dx.doi.org/10.1186/s12929-016-0233-8},
keywords = {Salt restriction; Low birth weight; Low birth rate; Programing; Growth retardation; Hypertension; Salt sensitivity; Insulin resistance; Dyslipidemia},
language = {eng},
issn = {1021-7770},
journal = {Journal of Biomedical Science},
title = {Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood},
volume = {23},
year = {2016}
}
TY - JOUR
ID - 1412160
AU - Sakuyama, Hiroe - Katoh, Minami - Wakabayashi, Honoka - Zulli, Anthony - Kružliak, Peter - Uehara, Yoshio
PY - 2016
TI - Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood
JF - Journal of Biomedical Science
VL - 23
IS - JAN 20 2016
SP - 1-9
EP - 1-9
PB - BioMed Central, London, England
SN - 10217770
KW - Salt restriction
KW - Low birth weight
KW - Low birth rate
KW - Programing
KW - Growth retardation
KW - Hypertension
KW - Salt sensitivity
KW - Insulin resistance
KW - Dyslipidemia
N2 - Recent studies reported the critical role of the intrauterine environment of a fetus in growth or the development of disease in adulthood. In this article we discussed the implications of salt restriction in growth of a fetus and the development of growth-related disease in adulthood. Salt restriction causes retardation of fatal growth or intrauterine death thereby leading to low birth weight or decreased birth rate. Such retardation of growth along with the upregulation of the renin angiotensin system due to salt restriction results in the underdevelopment of cardiovascular organs or decreases the number of the nephron in the kidney and is responsible for onset of hypertension in adulthood. In addition, gestational salt restriction is associated with salt craving after weaning. Moreover, salt restriction is associated with a decrease in insulin sensitivity. A series of alterations in metabolism due to salt restriction are probably mediated by the upregulation of the renin angiotensin system and an epigenetic mechanism including proinflammatory substances or histone methylation. Part of the metabolic disease in adulthood may be programmed through such epigenetic changes. The modification of gene in a fetus may be switched on through environment factors or life style after birth. The benefits of salt restriction have been assumed thus far; however, more precise investigation is required of its influence on the health of fetuses and the onset of various diseases in adulthood.
ER -
SAKUYAMA, Hiroe, Minami KATOH, Honoka WAKABAYASHI, Anthony ZULLI, Peter KRUŽLIAK and Yoshio UEHARA. Influence of gestational salt restriction in fetal growth and in development of diseases in adulthood. \textit{Journal of Biomedical Science}. BioMed website: BioMed Central, London, England, 2016, vol.~23, JAN 20 2016, p.~1-9. ISSN~1021-7770. Available from: https://dx.doi.org/10.1186/s12929-016-0233-8.
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