Looking for inhibitor: structural and functional analysis of novel bangle lectin PHL from Photorhabdus asymbiotica

HOUSER, Josef, Gita JANČAŘÍKOVÁ, Pavel DOBEŠ, Eva FUJDIAROVÁ, Pavel HYRŠL, Magdolna CSÁVÁS, Jitka MORAVCOVÁ and Michaela WIMMEROVÁ. Looking for inhibitor: structural and functional analysis of novel bangle lectin PHL from Photorhabdus asymbiotica. In XV Discussions in Structural Molecular Biology. 2018. ISSN 1211-5894.

Basic information

• Original name: Looking for inhibitor: structural and functional analysis of novel bangle lectin PHL from Photorhabdus asymbiotica
• Authors: HOUSER, Josef (203 Czech Republic, belonging to the institution), Gita JANČAŘÍKOVÁ (356 India, belonging to the institution), Pavel DOBEŠ (203 Czech Republic, belonging to the institution), Eva FUJDIAROVÁ (203 Czech Republic, belonging to the institution), Pavel HYRŠL (203 Czech Republic, belonging to the institution), Magdolna CSÁVÁS (348 Hungary), Jitka MORAVCOVÁ (203 Czech Republic) and Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: XV Discussions in Structural Molecular Biology, 2018.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14740/18:00100873
• Organization unit: Central European Institute of Technology
• ISSN: 1211-5894
• Keywords in English: lectins; pathogens; inhibitors; Photorhabdus
• Tags: rivok
• Tags: International impact

Abstract

In Photorhabdus asymbiotica genom, we identified a gene for a putative lectin, and examined the corresponding recombinant protein PHL from functional and structural point of view. We succeeded in determining structure of PHL in complex with several monosaccharides and tested a wide range of various mono-, di- and oligovalent carbohydrate-based molecules. Data gained so far show the way for design and synthesis of potential therapeutics.

Links

• CZ.02.1.01/0.0/0.0/16_013/0001776, interní kód MU(CEP code: EF16_013/0001776): Name: CIISB - Česká infrastruktura pro integrativní strukturní biologii pro lidské zdraví (Acronym: CIISB4HEALTH)

Investor: Ministry of Education, Youth and Sports of the CR, Czech Infrastructure for Integrative Structural Biology for Human Health, Priority axis 1: Strengthening capacities for high-quality research

• GA18-18964S, research and development project: Name: Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání

Investor: Czech Science Foundation

• LM2015043, research and development project: Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR