Prenatal exposure to modafinil alters behavioural response to
methamphetamine in adult male mice

J 2018

Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice

RUDÁ, Jana, Jana PISTOVČÁKOVÁ, Petra AMCHOVÁ, Alexandra ŠULCOVÁ, Alena MÁCHALOVÁ et. al.

Basic information

Original name

Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice

Name in Czech

Prenatální expozice modafinily ovlivňuje behaviorální účinky metamfetaminu u dospělých myších samců

Authors

RUDÁ, Jana (203 Czech Republic, guarantor, belonging to the institution), Jana PISTOVČÁKOVÁ (203 Czech Republic, belonging to the institution), Petra AMCHOVÁ (203 Czech Republic, belonging to the institution), Alexandra ŠULCOVÁ (203 Czech Republic, belonging to the institution) and Alena MÁCHALOVÁ (203 Czech Republic, belonging to the institution)

Edition

International Journal of Developmental Neuroscience, Oxford, Pergamon-Elsevier Science LTD, 2018, 0736-5748

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.367

RIV identification code

RIV/00216224:14110/18:00102507

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ijdevneu.2018.03.005

UT WoS

000431747700006

Keywords in English

Modafinil; Prenatal administration; Locomotion; Methamphetamine; Mice

Abstract

V originále

Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern The aim of this study was to assess behavioural and immune effects of prenatal modafinil exposure in mice and to evaluate the reaction to methamphetamine exposure on these animals in adult age. Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestation day (GD) 3 to GD 10 and then a challenge dose on GD 17. The male offspring were treated analogously at the age of 10 weeks with methamphetamine (2.5 mg/kg orally). changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-ay wash-out period One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. The modafinil prenatally exposed mice showed basal hypolocomotion, increased anxiety, lower locomotor effect of acute methamphetamine and increased vulnerability to behavioural sensitization The leukocyte activity did not show significant differences. Prenatal modafinil exposure alters basal behavioural profile, decreases acute effect of methamphetamine and enhances vulnerability to development of behavioural sensitization at adulthood This may lead to higher vulnerability to development of addiction.

Links

MUNI/A/1132/2017, interní kód MU

Name: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv

Investor: Masaryk University, Category A

Citovat

RUDÁ, Jana, Jana PISTOVČÁKOVÁ, Petra AMCHOVÁ, Alexandra ŠULCOVÁ and Alena MÁCHALOVÁ. Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice. International Journal of Developmental Neuroscience. Oxford: Pergamon-Elsevier Science LTD, 2018, vol. 67, JUN 2018, p. 37-45. ISSN 0736-5748. Available from: https://dx.doi.org/10.1016/j.ijdevneu.2018.03.005.

@article{1413195,
   author = {Rudá, Jana and Pistovčáková, Jana and Amchová, Petra and Šulcová, Alexandra and Máchalová, Alena},
   article_location = {Oxford},
   article_number = {JUN 2018},
   doi = {http://dx.doi.org/10.1016/j.ijdevneu.2018.03.005},
   keywords = {Modafinil; Prenatal administration; Locomotion; Methamphetamine; Mice},
   language = {eng},
   issn = {0736-5748},
   journal = {International Journal of Developmental Neuroscience},
   title = {Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice},
   url = {https://doi.org/10.1016/j.ijdevneu.2018.03.005},
   volume = {67},
   year = {2018}
}

TY  - JOUR
ID  - 1413195
AU  - Rudá, Jana - Pistovčáková, Jana - Amchová, Petra - Šulcová, Alexandra - Máchalová, Alena
PY  - 2018
TI  - Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice
JF  - International Journal of Developmental Neuroscience
VL  - 67
IS  - JUN 2018
SP  - 37-45
EP  - 37-45
PB  - Pergamon-Elsevier Science LTD
SN  - 07365748
KW  - Modafinil
KW  - Prenatal administration
KW  - Locomotion
KW  - Methamphetamine
KW  - Mice
UR  - https://doi.org/10.1016/j.ijdevneu.2018.03.005
L2  - https://doi.org/10.1016/j.ijdevneu.2018.03.005
N2  - Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy However, it is used as a "smart drug" especially by young adults to increase wakefulness, concentration and mental performance Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern The aim of this study was to assess behavioural and immune effects of prenatal modafinil exposure in mice and to evaluate the reaction to methamphetamine exposure on these animals in adult age. Pregnant female mice were given either saline or modafinil (50 mg/kg orally) from gestation day (GD) 3 to GD 10 and then a challenge dose on GD 17. The male offspring were treated analogously at the age of 10 weeks with methamphetamine (2.5 mg/kg orally). changes in the spontaneous locomotor/exploratory behaviour and anxiogenic profile in the open field test were assessed in naive animals, after an acute and 8th modafinil dose and the challenge dose following a 7-ay wash-out period One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol-aided chemiluminiscence assay in vitro. The modafinil prenatally exposed mice showed basal hypolocomotion, increased anxiety, lower locomotor effect of acute methamphetamine and increased vulnerability to behavioural sensitization The leukocyte activity did not show significant differences. Prenatal modafinil exposure alters basal behavioural profile, decreases acute effect of methamphetamine and enhances vulnerability to development of behavioural sensitization at adulthood This may lead to higher vulnerability to development of addiction.
ER  -

RUDÁ, Jana, Jana PISTOVČÁKOVÁ, Petra AMCHOVÁ, Alexandra ŠULCOVÁ and Alena MÁCHALOVÁ. Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice. \textit{International Journal of Developmental Neuroscience}. Oxford: Pergamon-Elsevier Science LTD, 2018, vol.~67, JUN 2018, p.~37-45. ISSN~0736-5748. Available from: https://dx.doi.org/10.1016/j.ijdevneu.2018.03.005.

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