| CHRENKOVA, Vanda, Vit HUBKA, Petr CETKOVSKY, Michal KOUBA, Barbora WEINBERGEROVÁ, Pavlina LYSKOVA, Ludmila HORNOFOVA a Petr HUBACEK. Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans. MYCOPATHOLOGIA. DORDRECHT: SPRINGER, roč. 183, č. 2, s. 423-429. ISSN 0301-486X. doi:10.1007/s11046-017-0223-8. 2018. |
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@article{1416019,
author = {Chrenkova, Vanda and Hubka, Vit and Cetkovsky, Petr and Kouba, Michal and Weinbergerová, Barbora and Lyskova, Pavlina and Hornofova, Ludmila and Hubacek, Petr},
article_location = {DORDRECHT},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s11046-017-0223-8},
keywords = {Aspergillus quadrilineatus; Haematopoietic stem cell transplant; Invasive aspergillosis; Aspergillus section Nidulantes},
language = {eng},
issn = {0301-486X},
journal = {MYCOPATHOLOGIA},
title = {Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans},
volume = {183},
year = {2018}
}
TY - JOUR
ID - 1416019
AU - Chrenkova, Vanda - Hubka, Vit - Cetkovsky, Petr - Kouba, Michal - Weinbergerová, Barbora - Lyskova, Pavlina - Hornofova, Ludmila - Hubacek, Petr
PY - 2018
TI - Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans
JF - MYCOPATHOLOGIA
VL - 183
IS - 2
SP - 423-429
EP - 423-429
PB - SPRINGER
SN - 0301486X
KW - Aspergillus quadrilineatus
KW - Haematopoietic stem cell transplant
KW - Invasive aspergillosis
KW - Aspergillus section Nidulantes
N2 - Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and beta-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.
ER -
CHRENKOVA, Vanda, Vit HUBKA, Petr CETKOVSKY, Michal KOUBA, Barbora WEINBERGEROVÁ, Pavlina LYSKOVA, Ludmila HORNOFOVA a Petr HUBACEK. Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans. \textit{MYCOPATHOLOGIA}. DORDRECHT: SPRINGER, roč.~183, č.~2, s.~423-429. ISSN~0301-486X. doi:10.1007/s11046-017-0223-8. 2018.
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