Detailed Information on Publication Record
2018
Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans
CHRENKOVA, Vanda, Vit HUBKA, Petr CETKOVSKY, Michal KOUBA, Barbora WEINBERGEROVÁ et. al.Basic information
Original name
Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans
Authors
CHRENKOVA, Vanda (203 Czech Republic, guarantor), Vit HUBKA (203 Czech Republic), Petr CETKOVSKY (203 Czech Republic), Michal KOUBA (203 Czech Republic), Barbora WEINBERGEROVÁ (203 Czech Republic, belonging to the institution), Pavlina LYSKOVA (203 Czech Republic), Ludmila HORNOFOVA (203 Czech Republic) and Petr HUBACEK (203 Czech Republic)
Edition
MYCOPATHOLOGIA, DORDRECHT, SPRINGER, 2018, 0301-486X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10612 Mycology
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.278
RIV identification code
RIV/00216224:14110/18:00102670
Organization unit
Faculty of Medicine
UT WoS
000427090500012
Keywords in English
Aspergillus quadrilineatus; Haematopoietic stem cell transplant; Invasive aspergillosis; Aspergillus section Nidulantes
Tags
International impact, Reviewed
Změněno: 10/2/2019 18:21, Soňa Böhmová
Abstract
V originále
Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and beta-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.