J 2018

Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans

CHRENKOVA, Vanda, Vit HUBKA, Petr CETKOVSKY, Michal KOUBA, Barbora WEINBERGEROVÁ et. al.

Basic information

Original name

Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans

Authors

CHRENKOVA, Vanda (203 Czech Republic, guarantor), Vit HUBKA (203 Czech Republic), Petr CETKOVSKY (203 Czech Republic), Michal KOUBA (203 Czech Republic), Barbora WEINBERGEROVÁ (203 Czech Republic, belonging to the institution), Pavlina LYSKOVA (203 Czech Republic), Ludmila HORNOFOVA (203 Czech Republic) and Petr HUBACEK (203 Czech Republic)

Edition

MYCOPATHOLOGIA, DORDRECHT, SPRINGER, 2018, 0301-486X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10612 Mycology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.278

RIV identification code

RIV/00216224:14110/18:00102670

Organization unit

Faculty of Medicine

UT WoS

000427090500012

Keywords in English

Aspergillus quadrilineatus; Haematopoietic stem cell transplant; Invasive aspergillosis; Aspergillus section Nidulantes

Tags

International impact, Reviewed
Změněno: 10/2/2019 18:21, Soňa Böhmová

Abstract

V originále

Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and beta-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.