Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Lucie MASOPUSTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK, Antonín FASSMANN, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. Journal of Oral Pathology & Medicine. Hoboken: Wiley, 2018, vol. 47, No 4, p. 434-439. ISSN 0904-2512. Available from: https://dx.doi.org/10.1111/jop.12694.

Basic information

• Original name: Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population
• Authors: SLEZÁKOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Lucie MASOPUSTOVÁ (203 Czech Republic, belonging to the institution), Jiřina BÁRTOVÁ (203 Czech Republic), Jitka PETANOVÁ (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Journal of Oral Pathology & Medicine, Hoboken, Wiley, 2018, 0904-2512.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30208 Dentistry, oral surgery and medicine
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.030
• RIV identification code: RIV/00216224:14110/18:00100920
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/jop.12694
• UT WoS: 000430125800016
• Keywords in English: NLRP3; NOD-like receptor; polymorphism; recurrent aphthous stomatitis
• Tags: 14110114, 14110130, 14110518, 14119612, EL OK, podil, rivok
• Tags: International impact, Reviewed

Abstract

Background: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be involved. The aim of our study was to investigate three single nucleotide polymor- phisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3 ), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population. Methods: A total of 207 subjects were included in this case-control study. Sixty- four patients with RAS and 143 healthy controls were genotyped by a method based on polymerase chain reaction using 5 0 nuclease TaqMan â assays. Detailed anamnestic, clinical, and laboratory data were obtained from all subjects. Results: The allele and genotype frequencies of NLRP3 polymorphisms (rs10754558 and rs3806265) between both groups were similar. However, statistically significant differences in NLRP3 rs4612666 genotypes between the patients with RAS and controls were found; carriers of the TT genotype had a higher risk of developing RAS than subjects with the CT+CC genotypes (OR = 14.69, 95%CI = 1.73-124.72, P = .004, P corr < .05). No associations between NLRP3 haplotypes and RAS were observed. Conclusions: Our study indicates that the NLRP3 rs4612666 polymorphism may be involved in the development of RAS in the Czech population.

Links

• GB14-37368G, research and development project: Name: Centrum orofaciálního vývoje a regenerace

Investor: Czech Science Foundation

• MUNI/A/0948/2016, interní kód MU: Name: Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba

Investor: Masaryk University, Category A

• NV15-29336A, research and development project: Name: Změny imunologické reaktivity u pacientů s recidivujícími aftami