Association of the NOD-like receptor 3 (NLRP3) gene variability
with recurrent aphthous stomatitis in the Czech population

J 2018

Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Lucie MASOPUSTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ et. al.

Basic information

Original name

Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

Authors

SLEZÁKOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Lucie MASOPUSTOVÁ (203 Czech Republic, belonging to the institution), Jiřina BÁRTOVÁ (203 Czech Republic), Jitka PETANOVÁ (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Oral Pathology & Medicine, Hoboken, Wiley, 2018, 0904-2512

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.030

RIV identification code

RIV/00216224:14110/18:00100920

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/jop.12694

UT WoS

000430125800016

Keywords in English

NLRP3; NOD-like receptor; polymorphism; recurrent aphthous stomatitis

Abstract

V originále

Background: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be involved. The aim of our study was to investigate three single nucleotide polymor- phisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3 ), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population. Methods: A total of 207 subjects were included in this case-control study. Sixty- four patients with RAS and 143 healthy controls were genotyped by a method based on polymerase chain reaction using 5 0 nuclease TaqMan â assays. Detailed anamnestic, clinical, and laboratory data were obtained from all subjects. Results: The allele and genotype frequencies of NLRP3 polymorphisms (rs10754558 and rs3806265) between both groups were similar. However, statistically significant differences in NLRP3 rs4612666 genotypes between the patients with RAS and controls were found; carriers of the TT genotype had a higher risk of developing RAS than subjects with the CT+CC genotypes (OR = 14.69, 95%CI = 1.73-124.72, P = .004, P corr < .05). No associations between NLRP3 haplotypes and RAS were observed. Conclusions: Our study indicates that the NLRP3 rs4612666 polymorphism may be involved in the development of RAS in the Czech population.

Links

GB14-37368G, research and development project

Name: Centrum orofaciálního vývoje a regenerace

Investor: Czech Science Foundation

MUNI/A/0948/2016, interní kód MU

Name: Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba

Investor: Masaryk University, Category A

NV15-29336A, research and development project

Name: Změny imunologické reaktivity u pacientů s recidivujícími aftami

Citovat

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Lucie MASOPUSTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK, Antonín FASSMANN, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. Journal of Oral Pathology & Medicine. Hoboken: Wiley, 2018, vol. 47, No 4, p. 434-439. ISSN 0904-2512. Available from: https://dx.doi.org/10.1111/jop.12694.

@article{1416044,
   author = {Slezáková, Simona and Bořilová Linhartová, Petra and Masopustová, Lucie and Bártová, Jiřina and Petanová, Jitka and Kuklínek, Pavel and Fassmann, Antonín and Dušek, Ladislav and Izakovičová Hollá, Lydie},
   article_location = {Hoboken},
   article_number = {4},
   doi = {http://dx.doi.org/10.1111/jop.12694},
   keywords = {NLRP3; NOD-like receptor; polymorphism; recurrent aphthous stomatitis},
   language = {eng},
   issn = {0904-2512},
   journal = {Journal of Oral Pathology & Medicine},
   title = {Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population},
   volume = {47},
   year = {2018}
}

TY  - JOUR
ID  - 1416044
AU  - Slezáková, Simona - Bořilová Linhartová, Petra - Masopustová, Lucie - Bártová, Jiřina - Petanová, Jitka - Kuklínek, Pavel - Fassmann, Antonín - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY  - 2018
TI  - Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population
JF  - Journal of Oral Pathology & Medicine
VL  - 47
IS  - 4
SP  - 434-439
EP  - 434-439
PB  - Wiley
SN  - 09042512
KW  - NLRP3
KW  - NOD-like receptor
KW  - polymorphism
KW  - recurrent aphthous stomatitis
N2  - Background: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be involved. The aim of our study was to investigate three single nucleotide polymor- phisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3 ), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population. Methods: A total of 207 subjects were included in this case-control study. Sixty- four patients with RAS and 143 healthy controls were genotyped by a method based on polymerase chain reaction using 5 0 nuclease TaqMan â assays. Detailed anamnestic, clinical, and laboratory data were obtained from all subjects. Results: The allele and genotype frequencies of NLRP3 polymorphisms (rs10754558 and rs3806265) between both groups were similar. However, statistically significant differences in NLRP3 rs4612666 genotypes between the patients with RAS and controls were found; carriers of the TT genotype had a higher risk of developing RAS than subjects with the CT+CC genotypes (OR = 14.69, 95%CI = 1.73-124.72, P = .004, P corr < .05). No associations between NLRP3 haplotypes and RAS were observed. Conclusions: Our study indicates that the NLRP3 rs4612666 polymorphism may be involved in the development of RAS in the Czech population.
ER  -

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Lucie MASOPUSTOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK, Antonín FASSMANN, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population. \textit{Journal of Oral Pathology \&{} Medicine}. Hoboken: Wiley, 2018, vol.~47, No~4, p.~434-439. ISSN~0904-2512. Available from: https://dx.doi.org/10.1111/jop.12694.

Detailed Information on Publication Record