J 2018

Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

BOŘILOVÁ LINHARTOVÁ, Petra, Tereza DEISSOVÁ, Kristína MUSILOVÁ, Lenka ŽÁČKOVÁ, Martina KUKLETOVÁ et. al.

Basic information

Original name

Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Authors

BOŘILOVÁ LINHARTOVÁ, Petra (203 Czech Republic, belonging to the institution), Tereza DEISSOVÁ (203 Czech Republic, belonging to the institution), Kristína MUSILOVÁ (203 Czech Republic, belonging to the institution), Lenka ŽÁČKOVÁ (203 Czech Republic, belonging to the institution), Martina KUKLETOVÁ (203 Czech Republic), Lubomír KUKLA (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Clinical Oral Investigations, Heidelberg, Springer Heidelberg, 2018, 1432-6981

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.453

RIV identification code

RIV/00216224:14110/18:00100931

Organization unit

Faculty of Medicine

DOI

UT WoS

000430387800027

Keywords (in Czech)

enamelin; genový polymorfizmus; zubní kaz; studie kontroly-případy; dočasná dentice; stálá dentice

Keywords in English

enamelin; gene polymorphism;dental caries;case-control study;primary dentition; permanent dentition

Tags

Tags

International impact, Reviewed
Změněno: 26/3/2019 10:29, Soňa Böhmová

Abstract

ORIG CZ

V originále

Objectives The enamelin gene (ENAM) polymorphism (rs12640848) was recently associated with dental caries in primary teeth in Polish children. The aims of the present study were to prove this association in primary dentition and to find a possible effect of this variant on caries development in permanent dentition in Czech children. Materials and methods This study comprised 905 Czech children. Totally, 187 children aged 2-6 years with primary dentition [78 healthy subjects (with decayed/missing/filled teeth, dmft = 0) and 109 patients with early childhood caries (ECC; dmft >= 1)] were included in this case-control study. In addition, 177 subjects aged 13-15 years without caries (DMFT = 0) and 541 children with dental caries (DMFT >= 1) in permanent dentition were selected from the ELSPAC study. Genotype determination of the ENAM polymorphism (rs12640848) was based on the TaqMan method. Results No significant differences in the allele or genotype frequencies between the caries-free children and those affected by dental caries were observed in both primary and permanent dentitions. Conclusions Lack of association between the ENAM polymorphism (rs12640848) and dental caries in Czech children was detected.

In Czech

Cílem této studie bylo potvrdit asociaci uvedeného polymorfizmu v dočasné dentici a analyzovat možný efekt této záměny při rozvoji zubního kazu ve stálém chrupu u českých dětí.

Links

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU
Name: RECETOX RI - OP VVV (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 1: Strengthening capacities for high-quality research
GB14-37368G, research and development project
Name: Centrum orofaciálního vývoje a regenerace
Investor: Czech Science Foundation
MUNI/A/0948/2016, interní kód MU
Name: Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba
Investor: Masaryk University, Category A
NV17-30439A, research and development project
Name: Moderní biotechnologické a behaviorální přístupy ve výzkumu zubního kazu a strategie jeho prevence
ROZV/24/LF/2018, interní kód MU
Name: LF - Příspěvek na IP 2108
Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects