| STRNADEL, Jan, Cassiano CARROMEU, Cedric BARDY, Michael NAVARRO, Oleksandr PLATOSHYN, Andreas N. GLUD, Silvia MARSALA, Jozef KAFKA, Atsushi MIYANOHARA, Tomohisa KATO JR., Takahiro TADOKORO, Michael P. HEFFERAN, Kota KAMIZATO, Tetsuya YOSHIZUMI, Stefan JUHAS, Jana JUHASOVA, Chak-Sum HO, Taba KHERADMAND, PeiXi CHEN, Dáša BOHAČIAKOVÁ, Marian HRUSKA-PLOCHAN, Andrew J. TODD, Shawn P. DRISCOLL, Thomas D. GLENN, Samuel L. PFAFF, Jiri KLIMA, Joseph CIACCI, Eric CURTIS, Fred H. GAGE, Jack BUI, Kazuhiko YAMADA, Alysson R. MUOTRI and Martin MARSALA. Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs. Science Translational Medicine. Washington: American Association for the Advancement of Science, 2018, vol. 10, No 440, p. 1-14. ISSN 1946-6234. Available from: https://dx.doi.org/10.1126/scitranslmed.aam6651. |
Other formats:
BibTeX
LaTeX
RIS
@article{1417346,
author = {Strnadel, Jan and Carromeu, Cassiano and Bardy, Cedric and Navarro, Michael and Platoshyn, Oleksandr and Glud, Andreas N. and Marsala, Silvia and Kafka, Jozef and Miyanohara, Atsushi and Kato Jr., Tomohisa and Tadokoro, Takahiro and Hefferan, Michael P. and Kamizato, Kota and Yoshizumi, Tetsuya and Juhas, Stefan and Juhasova, Jana and Ho, ChakandSum and Kheradmand, Taba and Chen, PeiXi and Bohačiaková, Dáša and HruskaandPlochan, Marian and Todd, Andrew J. and Driscoll, Shawn P. and Glenn, Thomas D. and Pfaff, Samuel L. and Klima, Jiri and Ciacci, Joseph and Curtis, Eric and Gage, Fred H. and Bui, Jack and Yamada, Kazuhiko and Muotri, Alysson R. and Marsala, Martin},
article_location = {Washington},
article_number = {440},
doi = {http://dx.doi.org/10.1126/scitranslmed.aam6651},
keywords = {cells derived; iPSC},
language = {eng},
issn = {1946-6234},
journal = {Science Translational Medicine},
title = {Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs},
url = {http://stm.sciencemag.org/content/10/440/eaam6651.short},
volume = {10},
year = {2018}
}
TY - JOUR
ID - 1417346
AU - Strnadel, Jan - Carromeu, Cassiano - Bardy, Cedric - Navarro, Michael - Platoshyn, Oleksandr - Glud, Andreas N. - Marsala, Silvia - Kafka, Jozef - Miyanohara, Atsushi - Kato Jr., Tomohisa - Tadokoro, Takahiro - Hefferan, Michael P. - Kamizato, Kota - Yoshizumi, Tetsuya - Juhas, Stefan - Juhasova, Jana - Ho, Chak-Sum - Kheradmand, Taba - Chen, PeiXi - Bohačiaková, Dáša - Hruska-Plochan, Marian - Todd, Andrew J. - Driscoll, Shawn P. - Glenn, Thomas D. - Pfaff, Samuel L. - Klima, Jiri - Ciacci, Joseph - Curtis, Eric - Gage, Fred H. - Bui, Jack - Yamada, Kazuhiko - Muotri, Alysson R. - Marsala, Martin
PY - 2018
TI - Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs
JF - Science Translational Medicine
VL - 10
IS - 440
SP - 1-14
EP - 1-14
PB - American Association for the Advancement of Science
SN - 19466234
KW - cells derived
KW - iPSC
UR - http://stm.sciencemag.org/content/10/440/eaam6651.short
N2 - The use of autologous (or syngeneic) cells derived from induced pluripotent stem cells (iPSCs) holds great promise for future clinical use in a wide range of diseases and injuries. It is expected that cell replacement therapies using autologous cells would forego the need for immunosuppression, otherwise required in allogeneic transplantations. However, recent studies have shown the unexpected immune rejection of undifferentiated autologous mouse iPSCs after transplantation. Whether similar immunogenic properties are maintained in iPSC-derived lineage-committed cells (such as neural precursors) is relatively unknown. We demonstrate that syngeneic porcine iPSC-derived neural precursor cell (NPC) transplantation to the spinal cord in the absence of immunosuppression is associated with long-term survival and neuronal and glial differentiation. No tumor formation was noted. Similar cell engraftment and differentiation were shown in spinally injured transiently immunosuppressed swine leukocyte antigen (SLA)–mismatched allogeneic pigs. These data demonstrate that iPSC-NPCs can be grafted into syngeneic recipients in the absence of immunosuppression and that temporary immunosuppression is sufficient to induce long-term immune tolerance after NPC engraftment into spinally injured allogeneic recipients. Collectively, our results show that iPSC-NPCs represent an alternative source of transplantable NPCs for the treatment of a variety of disorders affecting the spinal cord, including trauma, ischemia, or amyotrophic lateral sclerosis.
ER -
STRNADEL, Jan, Cassiano CARROMEU, Cedric BARDY, Michael NAVARRO, Oleksandr PLATOSHYN, Andreas N. GLUD, Silvia MARSALA, Jozef KAFKA, Atsushi MIYANOHARA, Tomohisa KATO JR., Takahiro TADOKORO, Michael P. HEFFERAN, Kota KAMIZATO, Tetsuya YOSHIZUMI, Stefan JUHAS, Jana JUHASOVA, Chak-Sum HO, Taba KHERADMAND, PeiXi CHEN, Dáša BOHAČIAKOVÁ, Marian HRUSKA-PLOCHAN, Andrew J. TODD, Shawn P. DRISCOLL, Thomas D. GLENN, Samuel L. PFAFF, Jiri KLIMA, Joseph CIACCI, Eric CURTIS, Fred H. GAGE, Jack BUI, Kazuhiko YAMADA, Alysson R. MUOTRI and Martin MARSALA. Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs. \textit{Science Translational Medicine}. Washington: American Association for the Advancement of Science, 2018, vol.~10, No~440, p.~1-14. ISSN~1946-6234. Available from: https://dx.doi.org/10.1126/scitranslmed.aam6651.
|
