Exercise-induced circulating microRNA changes in athletes in
various training scenarios

J 2018

Exercise-induced circulating microRNA changes in athletes in various training scenarios

HOŘÁK, Martin, Filip ZLÁMAL, Robert ILIEV, Jan KUČERA, Jan CACEK et. al.

Basic information

Original name

Exercise-induced circulating microRNA changes in athletes in various training scenarios

Authors

HOŘÁK, Martin (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Robert ILIEV (203 Czech Republic, belonging to the institution), Jan KUČERA (203 Czech Republic, belonging to the institution), Jan CACEK (203 Czech Republic, belonging to the institution), Lenka SVOBODOVÁ (203 Czech Republic, belonging to the institution), Zuzana HLAVOŇOVÁ (203 Czech Republic, belonging to the institution), Tomáš KALINA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Plos one, San Francisco, Public Library of Science, 2018, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.776

RIV identification code

RIV/00216224:14110/18:00102799

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0191060

UT WoS

000422652700028

Keywords in English

circulating microRNA

Abstract

V originále

Background The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT). Methods 30 young male athletes of white European origin (mean age: 22.5 +/- 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randomly assigned to three possible training scenarios: EXPL, HYP or HITT and participated in 8-week-long program in given arm. Blood plasma samples were collected at the baseline and at week 5 and 8 and anthropometric and physical activity parameters were measured. Pre- and post-intervention characteristics were compared and participants were further evaluated as responders (RES) or non-responders (NRES). RES/NRES status was established for the following characteristics: 300 degrees/s right leg extension (t300), 60 degrees/s right leg extension (t60), isometric extension (IE), vertical jump, isometric extension of the right leg and body fat percentage (BFP). Results No differences in miRNA levels were apparent between the intervention groups at baseline. No statistically significant prediction role was observed using crude univariate stepwise regression model analysis where RES/NRES status for t300, t60, IE, vertical jump and pFM was used as a dependent variable and miR-21, miR-222, miR-16 and miR-93 levels at baseline were used as independent variables. The baseline levels of miR-93 expressed an independent prediction role for responder status based on isometric extension of the right leg (beta estimate 0.76, 95% CI: -0.01; 1.53, p = 0.052). Discussion The results of the study indicate that 8-week-long explosive strength training, hypertrophic strength training and high-intensity interval training regimens are associated with significant changes in miR-16, mir-21, miR-222 and miR-93 levels compared to a baseline in athletic young men.

Links

EF15_003/0000469, research and development project

Name: Cetocoen Plus

Citovat

HOŘÁK, Martin, Filip ZLÁMAL, Robert ILIEV, Jan KUČERA, Jan CACEK, Lenka SVOBODOVÁ, Zuzana HLAVOŇOVÁ, Tomáš KALINA, Ondřej SLABÝ and Julie BIENERTOVÁ VAŠKŮ. Exercise-induced circulating microRNA changes in athletes in various training scenarios. Plos one. San Francisco: Public Library of Science, 2018, vol. 13, No 1, p. 1-14. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0191060.

@article{1418459,
   author = {Hořák, Martin and Zlámal, Filip and Iliev, Robert and Kučera, Jan and Cacek, Jan and Svobodová, Lenka and Hlavoňová, Zuzana and Kalina, Tomáš and Slabý, Ondřej and Bienertová Vašků, Julie},
   article_location = {San Francisco},
   article_number = {1},
   doi = {http://dx.doi.org/10.1371/journal.pone.0191060},
   keywords = {circulating microRNA},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Exercise-induced circulating microRNA changes in athletes in various training scenarios},
   volume = {13},
   year = {2018}
}

TY  - JOUR
ID  - 1418459
AU  - Hořák, Martin - Zlámal, Filip - Iliev, Robert - Kučera, Jan - Cacek, Jan - Svobodová, Lenka - Hlavoňová, Zuzana - Kalina, Tomáš - Slabý, Ondřej - Bienertová Vašků, Julie
PY  - 2018
TI  - Exercise-induced circulating microRNA changes in athletes in various training scenarios
JF  - Plos one
VL  - 13
IS  - 1
SP  - 1-14
EP  - 1-14
PB  - Public Library of Science
SN  - 19326203
KW  - circulating microRNA
N2  - Background The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT). Methods 30 young male athletes of white European origin (mean age: 22.5 +/- 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randomly assigned to three possible training scenarios: EXPL, HYP or HITT and participated in 8-week-long program in given arm. Blood plasma samples were collected at the baseline and at week 5 and 8 and anthropometric and physical activity parameters were measured. Pre- and post-intervention characteristics were compared and participants were further evaluated as responders (RES) or non-responders (NRES). RES/NRES status was established for the following characteristics: 300 degrees/s right leg extension (t300), 60 degrees/s right leg extension (t60), isometric extension (IE), vertical jump, isometric extension of the right leg and body fat percentage (BFP). Results No differences in miRNA levels were apparent between the intervention groups at baseline. No statistically significant prediction role was observed using crude univariate stepwise regression model analysis where RES/NRES status for t300, t60, IE, vertical jump and pFM was used as a dependent variable and miR-21, miR-222, miR-16 and miR-93 levels at baseline were used as independent variables. The baseline levels of miR-93 expressed an independent prediction role for responder status based on isometric extension of the right leg (beta estimate 0.76, 95% CI: -0.01; 1.53, p = 0.052). Discussion The results of the study indicate that 8-week-long explosive strength training, hypertrophic strength training and high-intensity interval training regimens are associated with significant changes in miR-16, mir-21, miR-222 and miR-93 levels compared to a baseline in athletic young men.
ER  -

HOŘÁK, Martin, Filip ZLÁMAL, Robert ILIEV, Jan KUČERA, Jan CACEK, Lenka SVOBODOVÁ, Zuzana HLAVOŇOVÁ, Tomáš KALINA, Ondřej SLABÝ and Julie BIENERTOVÁ VAŠKŮ. Exercise-induced circulating microRNA changes in athletes in various training scenarios. \textit{Plos one}. San Francisco: Public Library of Science, 2018, vol.~13, No~1, p.~1-14. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0191060.

Detailed Information on Publication Record