HOŘÁK, Martin, Filip ZLÁMAL, Robert ILIEV, Jan KUČERA, Jan CACEK, Lenka SVOBODOVÁ, Zuzana HLAVOŇOVÁ, Tomáš KALINA, Ondřej SLABÝ and Julie BIENERTOVÁ VAŠKŮ. Exercise-induced circulating microRNA changes in athletes in various training scenarios. Plos one. San Francisco: Public Library of Science, 2018, vol. 13, No 1, p. 1-14. ISSN 1932-6203. doi:10.1371/journal.pone.0191060.
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Basic information
Original name Exercise-induced circulating microRNA changes in athletes in various training scenarios
Authors HOŘÁK, Martin (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Robert ILIEV (203 Czech Republic, belonging to the institution), Jan KUČERA (203 Czech Republic, belonging to the institution), Jan CACEK (203 Czech Republic, belonging to the institution), Lenka SVOBODOVÁ (203 Czech Republic, belonging to the institution), Zuzana HLAVOŇOVÁ (203 Czech Republic, belonging to the institution), Tomáš KALINA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, guarantor, belonging to the institution).
Edition Plos one, San Francisco, Public Library of Science, 2018, 1932-6203.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.776
RIV identification code RIV/00216224:14110/18:00102799
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1371/journal.pone.0191060
UT WoS 000422652700028
Keywords in English circulating microRNA
Tags 14110518, EL OK, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 12/3/2019 10:15.
Abstract
Background The aim of the study was to compare selected extracellular miRNA levels (miR-16, miR-21, miR-93 and miR-222 with the response to 8-week-long explosive strength training (EXPL), hypertrophic strength training (HYP) and high-intensity interval training (HIIT). Methods 30 young male athletes of white European origin (mean age: 22.5 +/- 4.06 years) recruited at the Faculty of Sports Studies of Masaryk University were enrolled in this study. The study participants were randomly assigned to three possible training scenarios: EXPL, HYP or HITT and participated in 8-week-long program in given arm. Blood plasma samples were collected at the baseline and at week 5 and 8 and anthropometric and physical activity parameters were measured. Pre- and post-intervention characteristics were compared and participants were further evaluated as responders (RES) or non-responders (NRES). RES/NRES status was established for the following characteristics: 300 degrees/s right leg extension (t300), 60 degrees/s right leg extension (t60), isometric extension (IE), vertical jump, isometric extension of the right leg and body fat percentage (BFP). Results No differences in miRNA levels were apparent between the intervention groups at baseline. No statistically significant prediction role was observed using crude univariate stepwise regression model analysis where RES/NRES status for t300, t60, IE, vertical jump and pFM was used as a dependent variable and miR-21, miR-222, miR-16 and miR-93 levels at baseline were used as independent variables. The baseline levels of miR-93 expressed an independent prediction role for responder status based on isometric extension of the right leg (beta estimate 0.76, 95% CI: -0.01; 1.53, p = 0.052). Discussion The results of the study indicate that 8-week-long explosive strength training, hypertrophic strength training and high-intensity interval training regimens are associated with significant changes in miR-16, mir-21, miR-222 and miR-93 levels compared to a baseline in athletic young men.
Links
EF15_003/0000469, research and development projectName: Cetocoen Plus
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