ŠMAJS, David and Petra POSPÍŠILOVÁ. Macrolide resistance in yaws. Lancet. NEW YORK: ELSEVIER SCIENCE INC, 2018, vol. 391, No 10130, p. 1555-1556. ISSN 0140-6736. Available from: https://dx.doi.org/10.1016/S0140-6736(18)30205-8.
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Basic information
Original name Macrolide resistance in yaws
Authors ŠMAJS, David (203 Czech Republic, guarantor, belonging to the institution) and Petra POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution).
Edition Lancet, NEW YORK, ELSEVIER SCIENCE INC, 2018, 0140-6736.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10602 Biology , Evolutionary biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 59.102
RIV identification code RIV/00216224:14110/18:00102803
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/S0140-6736(18)30205-8
UT WoS 000430542700006
Keywords in English Macrolide resistance
Tags EL OK, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 23/4/2024 09:58.
Abstract
The study by Oriol Mitja and colleagues in The Lancet shows that a single round of mass administration of azithromycin is insufficient to achieve yaws eradication. It also represents the first report of a mutation in both 23S rRNA genes of the yaws-causing spirochaete, Treponema pallidum subspecies pertenue (T p pertenue), causing macrolide resistance in five epidemiologically linked patients. The mutation, A2059G, was previously reported in a patient with syphilis (caused by T p pallidum) with spiramycin treatment failure;2 it is one of two macrolide-resistant mutations previously detected in T p pallidum (the other is A2058G). Since its discovery, the A2059G mutation has been detected in T p pallidum isolates from patients with syphilis from Argentina,China, Czech Republic,the UK, Madagascar and the USA.
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