Macrolide resistance in yaws

ŠMAJS, David and Petra POSPÍŠILOVÁ. Macrolide resistance in yaws. Lancet. NEW YORK: ELSEVIER SCIENCE INC, 2018, vol. 391, No 10130, p. 1555-1556. ISSN 0140-6736. Available from: https://dx.doi.org/10.1016/S0140-6736(18)30205-8.

Basic information

Original name

Macrolide resistance in yaws

Authors

ŠMAJS, David (203 Czech Republic, guarantor, belonging to the institution) and Petra POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution)

Edition

Lancet, NEW YORK, ELSEVIER SCIENCE INC, 2018, 0140-6736

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10602 Biology , Evolutionary biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 59.102

RIV identification code

RIV/00216224:14110/18:00102803

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/S0140-6736(18)30205-8

UT WoS

000430542700006

Keywords in English

Macrolide resistance

Tags

EL OK, rivok

Tags

International impact, Reviewed

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Abstract

V originále

The study by Oriol Mitja and colleagues in The Lancet shows that a single round of mass administration of azithromycin is insufficient to achieve yaws eradication. It also represents the first report of a mutation in both 23S rRNA genes of the yaws-causing spirochaete, Treponema pallidum subspecies pertenue (T p pertenue), causing macrolide resistance in five epidemiologically linked patients. The mutation, A2059G, was previously reported in a patient with syphilis (caused by T p pallidum) with spiramycin treatment failure;2 it is one of two macrolide-resistant mutations previously detected in T p pallidum (the other is A2058G). Since its discovery, the A2059G mutation has been detected in T p pallidum isolates from patients with syphilis from Argentina,China, Czech Republic,the UK, Madagascar and the USA.