In their Article in The Lancet Global Health, Michael Marks and colleagues1 compare the efficacy of low-dose azithromycin (20 mg/kg) versus standard-dose azithromycin (30 mg/kg) for the treatment of yaws. The lower dose of azithromycin is commonly used for trachoma elimination and, since yaws and trachoma are co-endemic in several regions,2 mass treatment with low-dose azithromycin could also aid yaws eradication. If a low-dose azithromycin treatment is as effective against yaws as standard-dose azithromycin, yaws eradication programmes can expect a considerable cost saving.