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@article{1418478,
author = {Dostalek, L. and Zikan, M. and Fischerova, D. and Kocian, R. and Germanova, A. and Fruhauf, F. and Dušek, Ladislav and Slama, J. and Dundr, P. and Nemejcova, K. and Cibula, D.},
article_location = {SAN DIEGO},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.ygyno.2018.01.001},
keywords = {Cervical cancer; Bulky; Sentinel lymph node; False negative rate; Detection rate; Sensitivity},
language = {eng},
issn = {0090-8258},
journal = {Gynecologic Oncology},
title = {SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm},
volume = {148},
year = {2018}
}
TY - JOUR
ID - 1418478
AU - Dostalek, L. - Zikan, M. - Fischerova, D. - Kocian, R. - Germanova, A. - Fruhauf, F. - Dušek, Ladislav - Slama, J. - Dundr, P. - Nemejcova, K. - Cibula, D.
PY - 2018
TI - SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm
JF - Gynecologic Oncology
VL - 148
IS - 3
SP - 456-460
EP - 456-460
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 00908258
KW - Cervical cancer
KW - Bulky
KW - Sentinel lymph node
KW - False negative rate
KW - Detection rate
KW - Sensitivity
N2 - Objectives. The aim of this study was to assess the detection rate, false-negative rate and sensitivity of SLN in LN staging in tumors over 2 cm on a large cohort of patients. Methods. Data from patients with stages pT1a - pT2 cervical cancer who underwent surgical treatment, including SLN biopsy followed by systematic pelvic lymphadenectomy, were retrospectively analyzed. A combined technique with blue dye and radiocolloid was modified in larger tumors to inject the tracer into the residual cervical stroma. Results. The study included 350 patients with stages pTla - pT2. Macrometastases, micrometastases, and isolated tumor cells were found in 10%, 8%, and 4% of cases. Bilateral detection rate was similar in subgroups with tumors < 2 cm, 2-3.9 cm, and >= 4 cm (79%, 83%, 76%) (P = 0.460). There were only two cases with false-negative SLN ultrastaging for pelvic IN status among those with bilateral SLN detection. The false negative rate was very low in all three subgroups of different tumor sizes (0.9%, 0.9%, and 0.0%; P = 0.999). Sensitivity reached 96% in the whole group and was high in all three groups (93%, 93%, 100%; P = 0.510). Conclusions. If the tracer application technique is adjusted in larger tumors, SIN biopsy can be equally reliable in pelvic IN staging in tumors smaller and larger than 2 cm. The bilateral detection rate and false negative rate did not differ in subgroups of patients with tumors < 2 cm, 2-3.9 cm, and cm.
ER -
DOSTALEK, L., M. ZIKAN, D. FISCHEROVA, R. KOCIAN, A. GERMANOVA, F. FRUHAUF, Ladislav DUŠEK, J. SLAMA, P. DUNDR, K. NEMEJCOVA and D. CIBULA. SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm. \textit{Gynecologic Oncology}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, vol.~148, No~3, p.~456-460. ISSN~0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2018.01.001.
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