SLN biopsy in cervical cancer patients with tumors larger than
2 cm and 4 cm

J 2018

SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm

DOSTALEK, L., M. ZIKAN, D. FISCHEROVA, R. KOCIAN, A. GERMANOVA et. al.

Basic information

Original name

SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm

Authors

DOSTALEK, L. (203 Czech Republic), M. ZIKAN (203 Czech Republic), D. FISCHEROVA (203 Czech Republic), R. KOCIAN (203 Czech Republic), A. GERMANOVA (203 Czech Republic), F. FRUHAUF (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), J. SLAMA (203 Czech Republic), P. DUNDR (203 Czech Republic), K. NEMEJCOVA (203 Czech Republic) and D. CIBULA (203 Czech Republic, guarantor)

Edition

Gynecologic Oncology, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, 0090-8258

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.393

RIV identification code

RIV/00216224:14110/18:00102807

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ygyno.2018.01.001

UT WoS

000428005300005

Keywords in English

Cervical cancer; Bulky; Sentinel lymph node; False negative rate; Detection rate; Sensitivity

Abstract

V originále

Objectives. The aim of this study was to assess the detection rate, false-negative rate and sensitivity of SLN in LN staging in tumors over 2 cm on a large cohort of patients. Methods. Data from patients with stages pT1a - pT2 cervical cancer who underwent surgical treatment, including SLN biopsy followed by systematic pelvic lymphadenectomy, were retrospectively analyzed. A combined technique with blue dye and radiocolloid was modified in larger tumors to inject the tracer into the residual cervical stroma. Results. The study included 350 patients with stages pTla - pT2. Macrometastases, micrometastases, and isolated tumor cells were found in 10%, 8%, and 4% of cases. Bilateral detection rate was similar in subgroups with tumors < 2 cm, 2-3.9 cm, and >= 4 cm (79%, 83%, 76%) (P = 0.460). There were only two cases with false-negative SLN ultrastaging for pelvic IN status among those with bilateral SLN detection. The false negative rate was very low in all three subgroups of different tumor sizes (0.9%, 0.9%, and 0.0%; P = 0.999). Sensitivity reached 96% in the whole group and was high in all three groups (93%, 93%, 100%; P = 0.510). Conclusions. If the tracer application technique is adjusted in larger tumors, SIN biopsy can be equally reliable in pelvic IN staging in tumors smaller and larger than 2 cm. The bilateral detection rate and false negative rate did not differ in subgroups of patients with tumors < 2 cm, 2-3.9 cm, and cm.

Citovat

DOSTALEK, L., M. ZIKAN, D. FISCHEROVA, R. KOCIAN, A. GERMANOVA, F. FRUHAUF, Ladislav DUŠEK, J. SLAMA, P. DUNDR, K. NEMEJCOVA and D. CIBULA. SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm. Gynecologic Oncology. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, vol. 148, No 3, p. 456-460. ISSN 0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2018.01.001.

@article{1418478,
   author = {Dostalek, L. and Zikan, M. and Fischerova, D. and Kocian, R. and Germanova, A. and Fruhauf, F. and Dušek, Ladislav and Slama, J. and Dundr, P. and Nemejcova, K. and Cibula, D.},
   article_location = {SAN DIEGO},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.ygyno.2018.01.001},
   keywords = {Cervical cancer; Bulky; Sentinel lymph node; False negative rate; Detection rate; Sensitivity},
   language = {eng},
   issn = {0090-8258},
   journal = {Gynecologic Oncology},
   title = {SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm},
   volume = {148},
   year = {2018}
}

TY  - JOUR
ID  - 1418478
AU  - Dostalek, L. - Zikan, M. - Fischerova, D. - Kocian, R. - Germanova, A. - Fruhauf, F. - Dušek, Ladislav - Slama, J. - Dundr, P. - Nemejcova, K. - Cibula, D.
PY  - 2018
TI  - SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm
JF  - Gynecologic Oncology
VL  - 148
IS  - 3
SP  - 456-460
EP  - 456-460
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 00908258
KW  - Cervical cancer
KW  - Bulky
KW  - Sentinel lymph node
KW  - False negative rate
KW  - Detection rate
KW  - Sensitivity
N2  - Objectives. The aim of this study was to assess the detection rate, false-negative rate and sensitivity of SLN in LN staging in tumors over 2 cm on a large cohort of patients. Methods. Data from patients with stages pT1a - pT2 cervical cancer who underwent surgical treatment, including SLN biopsy followed by systematic pelvic lymphadenectomy, were retrospectively analyzed. A combined technique with blue dye and radiocolloid was modified in larger tumors to inject the tracer into the residual cervical stroma. Results. The study included 350 patients with stages pTla - pT2. Macrometastases, micrometastases, and isolated tumor cells were found in 10%, 8%, and 4% of cases. Bilateral detection rate was similar in subgroups with tumors < 2 cm, 2-3.9 cm, and >= 4 cm (79%, 83%, 76%) (P = 0.460). There were only two cases with false-negative SLN ultrastaging for pelvic IN status among those with bilateral SLN detection. The false negative rate was very low in all three subgroups of different tumor sizes (0.9%, 0.9%, and 0.0%; P = 0.999). Sensitivity reached 96% in the whole group and was high in all three groups (93%, 93%, 100%; P = 0.510). Conclusions. If the tracer application technique is adjusted in larger tumors, SIN biopsy can be equally reliable in pelvic IN staging in tumors smaller and larger than 2 cm. The bilateral detection rate and false negative rate did not differ in subgroups of patients with tumors < 2 cm, 2-3.9 cm, and cm.
ER  -

DOSTALEK, L., M. ZIKAN, D. FISCHEROVA, R. KOCIAN, A. GERMANOVA, F. FRUHAUF, Ladislav DUŠEK, J. SLAMA, P. DUNDR, K. NEMEJCOVA and D. CIBULA. SLN biopsy in cervical cancer patients with tumors larger than 2 cm and 4 cm. \textit{Gynecologic Oncology}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, vol.~148, No~3, p.~456-460. ISSN~0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2018.01.001.

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