Detailed Information on Publication Record
2018
A positive dose-response of quercetin on compact bone microstructure of male rabbits
BABOSOVA, Ramona, Radoslav OMELKA, Maria ADAMKOVICOVA, Patrik SRANKO, Michaela RAČANSKÁ et. al.Basic information
Original name
A positive dose-response of quercetin on compact bone microstructure of male rabbits
Authors
BABOSOVA, Ramona (703 Slovakia, guarantor), Radoslav OMELKA (703 Slovakia), Maria ADAMKOVICOVA (703 Slovakia), Patrik SRANKO (703 Slovakia), Michaela RAČANSKÁ (203 Czech Republic, belonging to the institution), Roman TOMAN (703 Slovakia), Marcela CAPCAROVA (703 Slovakia) and Monika MARTINIAKOVA (703 Slovakia)
Edition
Journal of Microbiology, Biotechnology and Food Sciences, Nitra, Slovak University of Agriculture, 2018, 1338-5178
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30106 Anatomy and morphology
Country of publisher
Slovakia
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/18:00102834
Organization unit
Faculty of Medicine
UT WoS
000455216600005
Keywords in English
Bone microstructure; Histology; Quercetin; Rabbit
Tags
International impact, Reviewed
Změněno: 21/2/2019 12:26, Soňa Böhmová
Abstract
V originále
Quercetin is one of the most widely distributed flavonoids in plants which should have a broad range of significant health promoting properties. Its effect on bone microstructure of males has not been sufficiently investigated. Therefore, our study was aimed to determine the impact of quercetin on femoral bone microstructure in 5-month-old male rabbits. Nine rabbits were intramuscularly injected with following doses of quercetin: 10 micro g/kg body weight (bw) (E1 group; n=3), 100 micro g/kg bw (E2 group; n=3) and 1000 micro g/kg bw (E3 group; n=3) for 90 days, 3 times per week. Three rabbits without quercetin administration served as a control group. An accelerated bone resorption at the endosteal surface and intensive periosteal bone apposition were observed in all rabbits administered quercetin. However, the most evident changes such as a thicker layer of primary vascular longitudinal bone tissue under periosteum and a lower density of secondary osteons were identified in males from the E3 group. Morphometrical evaluations of the compact bone showed significantly decreased sizes of primary osteons' vascular canals and secondary osteons in rabbits exposed to the highest dose of quercetin. Sizes of secondary osteons were also lower in males from the E2 group. Our results demonstrate that quercetin has a positive dose-response on compact bone microstructure in male rabbits.