| BABOSOVA, Ramona, Radoslav OMELKA, Maria ADAMKOVICOVA, Patrik SRANKO, Michaela RAČANSKÁ, Roman TOMAN, Marcela CAPCAROVA and Monika MARTINIAKOVA. A positive dose-response of quercetin on compact bone microstructure of male rabbits. Journal of Microbiology, Biotechnology and Food Sciences. Nitra: Slovak University of Agriculture, 2018, vol. 7, No 5, p. 469-472. ISSN 1338-5178. Available from: https://dx.doi.org/10.15414/jmbfs.2018.7.5.469-472. |
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@article{1418978,
author = {Babosova, Ramona and Omelka, Radoslav and Adamkovicova, Maria and Sranko, Patrik and Račanská, Michaela and Toman, Roman and Capcarova, Marcela and Martiniakova, Monika},
article_location = {Nitra},
article_number = {5},
doi = {http://dx.doi.org/10.15414/jmbfs.2018.7.5.469-472},
keywords = {Bone microstructure; Histology; Quercetin; Rabbit},
language = {eng},
issn = {1338-5178},
journal = {Journal of Microbiology, Biotechnology and Food Sciences},
title = {A positive dose-response of quercetin on compact bone microstructure of male rabbits},
volume = {7},
year = {2018}
}
TY - JOUR
ID - 1418978
AU - Babosova, Ramona - Omelka, Radoslav - Adamkovicova, Maria - Sranko, Patrik - Račanská, Michaela - Toman, Roman - Capcarova, Marcela - Martiniakova, Monika
PY - 2018
TI - A positive dose-response of quercetin on compact bone microstructure of male rabbits
JF - Journal of Microbiology, Biotechnology and Food Sciences
VL - 7
IS - 5
SP - 469-472
EP - 469-472
PB - Slovak University of Agriculture
SN - 13385178
KW - Bone microstructure
KW - Histology
KW - Quercetin
KW - Rabbit
N2 - Quercetin is one of the most widely distributed flavonoids in plants which should have a broad range of significant health promoting properties. Its effect on bone microstructure of males has not been sufficiently investigated. Therefore, our study was aimed to determine the impact of quercetin on femoral bone microstructure in 5-month-old male rabbits. Nine rabbits were intramuscularly injected with following doses of quercetin: 10 micro g/kg body weight (bw) (E1 group; n=3), 100 micro g/kg bw (E2 group; n=3) and 1000 micro g/kg bw (E3 group; n=3) for 90 days, 3 times per week. Three rabbits without quercetin administration served as a control group. An accelerated bone resorption at the endosteal surface and intensive periosteal bone apposition were observed in all rabbits administered quercetin. However, the most evident changes such as a thicker layer of primary vascular longitudinal bone tissue under periosteum and a lower density of secondary osteons were identified in males from the E3 group. Morphometrical evaluations of the compact bone showed significantly decreased sizes of primary osteons' vascular canals and secondary osteons in rabbits exposed to the highest dose of quercetin. Sizes of secondary osteons were also lower in males from the E2 group. Our results demonstrate that quercetin has a positive dose-response on compact bone microstructure in male rabbits.
ER -
BABOSOVA, Ramona, Radoslav OMELKA, Maria ADAMKOVICOVA, Patrik SRANKO, Michaela RAČANSKÁ, Roman TOMAN, Marcela CAPCAROVA and Monika MARTINIAKOVA. A positive dose-response of quercetin on compact bone microstructure of male rabbits. \textit{Journal of Microbiology, Biotechnology and Food Sciences}. Nitra: Slovak University of Agriculture, 2018, vol.~7, No~5, p.~469-472. ISSN~1338-5178. Available from: https://dx.doi.org/10.15414/jmbfs.2018.7.5.469-472.
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