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@article{1419298,
author = {Lebedová, Jana and Nováková, Zuzana and Vecera, Z. and Buchtová, marcela and Dumková, Jana and Docekal, B. and Bláhová, Lucie and Mikuska, P. and Misek, I. and Hampl, Aleš and Hilscherová, Klára},
article_location = {ABINGDON},
article_number = {4},
doi = {http://dx.doi.org/10.1080/17435390.2018.1438679},
keywords = {Nanoparticles; subchronic; lead; oxidative stress; accumulation; tissue damage},
language = {eng},
issn = {1743-5390},
journal = {NANOTOXICOLOGY},
title = {Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice},
url = {https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1438679},
volume = {12},
year = {2018}
}
TY - JOUR
ID - 1419298
AU - Lebedová, Jana - Nováková, Zuzana - Vecera, Z. - Buchtová, marcela - Dumková, Jana - Docekal, B. - Bláhová, Lucie - Mikuska, P. - Misek, I. - Hampl, Aleš - Hilscherová, Klára
PY - 2018
TI - Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice
JF - NANOTOXICOLOGY
VL - 12
IS - 4
SP - 290-304
EP - 290-304
PB - TAYLOR & FRANCIS LTD
SN - 17435390
KW - Nanoparticles
KW - subchronic
KW - lead
KW - oxidative stress
KW - accumulation
KW - tissue damage
UR - https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1438679
L2 - https://www.tandfonline.com/doi/full/10.1080/17435390.2018.1438679
N2 - Lead nanoparticles (NPs) are released into air from metal processing, road transport or combustion processes. Inhalation exposure is therefore very likely to occur. However, even though the effects of bulk lead are well known, there is limited knowledge regarding impact of Pb NPs inhalation. This study focused on acute and subchronic exposures to lead oxide nanoparticles (PbO NPs). Mice were exposed to PbO NPs in whole body inhalation chambers for 4-72h in acute experiment (4.05x10(6) PbO NPs/cm(3)), and for 1-11 weeks in subchronic experiment (3.83x10(5) particles/cm(3) in lower and 1.93x10(6) particles/cm(3) in higher exposure group). Presence of NPs was confirmed in all studied organs, including brain, which is very important considering lead neurotoxicity. Lead concentration gradually increased in all tissues depending on the exposure concentration and duration. The most burdened organs were lung and kidney, however liver and brain also showed significant increase of lead concentration during exposure. Histological analysis documented numerous morphological alterations and tissue damage, mainly in lung, but also in liver. Mild pathological changes were observed also in kidney and brain. Levels of glutathione (reduced and oxidized) were modulated mainly in lung in both, acute and subchronic exposures. Increase of lipid peroxidation was observed in kidney after acute exposure. This study characterized impacts of short to longer-term inhalation exposure, proved transport of PbO NPs to secondary organs, documented time and concentration dependent gradual increase of Pb concentration and histopathological damage in tissues.
ER -
LEBEDOVÁ, Jana, Zuzana NOVÁKOVÁ, Z. VECERA, marcela BUCHTOVÁ, Jana DUMKOVÁ, B. DOCEKAL, Lucie BLÁHOVÁ, P. MIKUSKA, I. MISEK, Aleš HAMPL and Klára HILSCHEROVÁ. Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice. \textit{NANOTOXICOLOGY}. ABINGDON: TAYLOR \&{}amp; FRANCIS LTD, 2018, vol.~12, No~4, p.~290-304. ISSN~1743-5390. Available from: https://dx.doi.org/10.1080/17435390.2018.1438679.
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