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@article{1419749,
author = {Pacík, Dalibor and Plevová, Mariana and Urbanova, Lucie and Lackova, Zuzana and Strmiska, Vladislav and Necas, Alois and Heger, Zbynek and Adam, Vojtech},
article_location = {London},
article_number = {4958},
doi = {http://dx.doi.org/10.1038/s41598-018-23072-4},
keywords = {URINE SAMPLES; CANCER; DOGS; MELANOMA},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma},
volume = {8},
year = {2018}
}
TY - JOUR
ID - 1419749
AU - Pacík, Dalibor - Plevová, Mariana - Urbanova, Lucie - Lackova, Zuzana - Strmiska, Vladislav - Necas, Alois - Heger, Zbynek - Adam, Vojtech
PY - 2018
TI - Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma
JF - Scientific reports
VL - 8
IS - 4958
SP - 1-5
EP - 1-5
PB - Nature Publishing Group
SN - 20452322
KW - URINE SAMPLES
KW - CANCER
KW - DOGS
KW - MELANOMA
N2 - The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.
ER -
PACÍK, Dalibor, Mariana PLEVOVÁ, Lucie URBANOVA, Zuzana LACKOVA, Vladislav STRMISKA, Alois NECAS, Zbynek HEGER a Vojtech ADAM. Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma. \textit{Scientific reports}. London: Nature Publishing Group, 2018, roč.~8, č.~4958, s.~1-5. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-018-23072-4.
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