Detailed Information on Publication Record

PACÍK, Dalibor, Mariana PLEVOVÁ, Lucie URBANOVA, Zuzana LACKOVA, Vladislav STRMISKA, Alois NECAS, Zbynek HEGER and Vojtech ADAM. Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma. Scientific reports. London: Nature Publishing Group, 2018, vol. 8, No 4958, p. 1-5. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-23072-4.

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Basic information
Original name	Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma
Authors	PACÍK, Dalibor (203 Czech Republic, belonging to the institution), Mariana PLEVOVÁ (703 Slovakia, belonging to the institution), Lucie URBANOVA (203 Czech Republic), Zuzana LACKOVA (203 Czech Republic), Vladislav STRMISKA (203 Czech Republic), Alois NECAS (203 Czech Republic), Zbynek HEGER (203 Czech Republic) and Vojtech ADAM (203 Czech Republic, guarantor).
Edition	Scientific reports, London, Nature Publishing Group, 2018, 2045-2322.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	30217 Urology and nephrology
Country of publisher	United Kingdom of Great Britain and Northern Ireland
Confidentiality degree	is not subject to a state or trade secret
Impact factor	Impact factor: 4.011
RIV identification code	RIV/00216224:14110/18:00102914
Organization unit	Faculty of Medicine
Doi	http://dx.doi.org/10.1038/s41598-018-23072-4
UT WoS	000427926500002
Keywords in English	URINE SAMPLES; CANCER; DOGS; MELANOMA
Tags	14110225, EL OK, rivok
Tags	International impact, Reviewed
Changed by	Changed by: Soňa Böhmová, učo 232884. Changed: 10/2/2019 13:52.

Abstract
The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.

Abstract

The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.