Identification of Sarcosine as a Target Molecule for the Canine
Olfactory Detection of Prostate Carcinoma

J 2018

Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

PACÍK, Dalibor, Mariana PLEVOVÁ, Lucie URBANOVA, Zuzana LACKOVA, Vladislav STRMISKA et. al.

Basic information

Original name

Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma

Authors

PACÍK, Dalibor (203 Czech Republic, belonging to the institution), Mariana PLEVOVÁ (703 Slovakia, belonging to the institution), Lucie URBANOVA (203 Czech Republic), Zuzana LACKOVA (203 Czech Republic), Vladislav STRMISKA (203 Czech Republic), Alois NECAS (203 Czech Republic), Zbynek HEGER (203 Czech Republic) and Vojtech ADAM (203 Czech Republic, guarantor)

Edition

Scientific reports, London, Nature Publishing Group, 2018, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30217 Urology and nephrology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.011

RIV identification code

RIV/00216224:14110/18:00102914

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-018-23072-4

UT WoS

000427926500002

Keywords in English

URINE SAMPLES; CANCER; DOGS; MELANOMA

Abstract

V originále

The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.

Citovat

PACÍK, Dalibor, Mariana PLEVOVÁ, Lucie URBANOVA, Zuzana LACKOVA, Vladislav STRMISKA, Alois NECAS, Zbynek HEGER and Vojtech ADAM. Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma. Scientific reports. London: Nature Publishing Group, 2018, vol. 8, No 4958, p. 1-5. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-23072-4.

@article{1419749,
   author = {Pacík, Dalibor and Plevová, Mariana and Urbanova, Lucie and Lackova, Zuzana and Strmiska, Vladislav and Necas, Alois and Heger, Zbynek and Adam, Vojtech},
   article_location = {London},
   article_number = {4958},
   doi = {http://dx.doi.org/10.1038/s41598-018-23072-4},
   keywords = {URINE SAMPLES; CANCER; DOGS; MELANOMA},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma},
   volume = {8},
   year = {2018}
}

TY  - JOUR
ID  - 1419749
AU  - Pacík, Dalibor - Plevová, Mariana - Urbanova, Lucie - Lackova, Zuzana - Strmiska, Vladislav - Necas, Alois - Heger, Zbynek - Adam, Vojtech
PY  - 2018
TI  - Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma
JF  - Scientific reports
VL  - 8
IS  - 4958
SP  - 1-5
EP  - 1-5
PB  - Nature Publishing Group
SN  - 20452322
KW  - URINE SAMPLES
KW  - CANCER
KW  - DOGS
KW  - MELANOMA
N2  - The hypothesis that dogs can detect malignant tumours through the identification of specific molecules is nearly 30 years old. To date, several reports have described the successful detection of distinct types of cancer. However, is still a lack of data regarding the specific molecules that can be recognized by a dog's olfactory apparatus. Hence, we performed a study with artificially prepared, well-characterized urinary specimens that were enriched with sarcosine, a widely reported urinary biomarker for prostate cancer (PCa). For the purposes of the study, a German shepherd dog was utilized for analyses of 60 positive and 120 negative samples. Our study provides the first evidence that a sniffer dog specially trained for the olfactory detection of PCa can recognize sarcosine in artificial urine with a performance [sensitivity of 90%, specificity of 95%, and precision of 90% for the highest amount of sarcosine (10 mu mol/ L)] that is comparable to the identification of PCa-diagnosed subjects (sensitivity of 93.5% and specificity of 91.6%). This study casts light on the unrevealed phenomenon of PCa olfactory detection and opens the door for further studies with canine olfactory detection and cancer diagnostics.
ER  -

PACÍK, Dalibor, Mariana PLEVOVÁ, Lucie URBANOVA, Zuzana LACKOVA, Vladislav STRMISKA, Alois NECAS, Zbynek HEGER and Vojtech ADAM. Identification of Sarcosine as a Target Molecule for the Canine Olfactory Detection of Prostate Carcinoma. \textit{Scientific reports}. London: Nature Publishing Group, 2018, vol.~8, No~4958, p.~1-5. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-23072-4.

Detailed Information on Publication Record