MAREČKOVÁ, Klára, Radek MAREČEK, Petra BENCÚROVÁ, Jana KLÁNOVÁ, Ladislav DUŠEK and Milan BRÁZDIL. Perinatal stress and human hippocampal volume: Findings from typically developing young adults. Scientific reports. London: NATURE PUBLISHING GROUP, vol. 8, MAR, p. 4696-4705. ISSN 2045-2322. doi:10.1038/s41598-018-23046-6. 2018.
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Basic information
Original name Perinatal stress and human hippocampal volume: Findings from typically developing young adults
Authors MAREČKOVÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Petra BENCÚROVÁ (703 Slovakia, belonging to the institution), Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution).
Edition Scientific reports, London, NATURE PUBLISHING GROUP, 2018, 2045-2322.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30103 Neurosciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.011
RIV identification code RIV/00216224:14740/18:00102939
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1038/s41598-018-23046-6
UT WoS 000427587600009
Keywords in English EARLY-LIFE STRESS; CHRONIC PSYCHOSOCIAL STRESS; MAJOR DEPRESSIVE DISORDER; CA3 PYRAMIDAL NEURONS; IN-VIVO MRI; DENTATE GYRUS; CHILDHOOD MALTREATMENT; PRENATAL STRESS; PSYCHOLOGICAL TRAUMA; PATTERN SEPARATION
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 13/3/2019 16:35.
Abstract
The main objective of this study was to investigate the impact of prenatal and early postnatal stress on hippocampal volume in young adulthood. In sharp contrast to numerous results in animal models, our data from a neuroimaging follow-up (n = 131) of a community-based birth cohort from the Czech Republic (European Longitudinal Study of Pregnancy and Childhood) showed that in typically developing young adults, hippocampal volume was not associated with birth weight, stressful life events during the prenatal or early postnatal period, or dysregulated mood and wellbeing in the mother during the early postnatal period. Interestingly, mother's anxiety/co-dependence during the first weeks after birth did show long-lasting effects on the hippocampal volume in young adult offspring irrespective of sex. Further analyses revealed that these effects were subfield-specific; present in CA1, CA2/3, CA4, GC-DG, subiculum, molecular layer, and HATA, hippocampal subfields identified by translational research as most stress-and glucocorticoid-sensitive, but not in the remaining subfields. Our findings provide evidence that the type of early stress is critical when studying its effects on the human brain.
Links
LM2015051, research and development projectName: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
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